Abstract
The pathogenesis of neurodegenerative diseases such as Parkinsons disease, amyotrophic lateral sclerosis and Alzheimers disease is unknown. These diseases are characterized by a slow, progressive loss of particular subsets of neurons. Much evidence has accumulated which supports the hypothesis that oxidative stress and damage by free radicals may play an important part in these diseases. In particular, recent studies with the inherited form of amyotrophic lateral sclerosis have revealed mutations in the superoxide dismutase gene, which is one of the cells main defence mechanisms against oxidative stress. These findings suggest a direct link between oxidative stress and the development of a neurodegenerative disease.
| Original language | English (Ireland) |
|---|---|
| Title of host publication | Oxidative stress and apoptosis in neurodegeneration |
| Number of pages | 8 |
| Volume | 139 |
| Publication status | Published - 1 Aug 1996 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Gorman, AM,McGowan, A,ONeill, C,Cotter, T