Isolation of a conserved sequence deleted in duchenne muscular dystrophy patients

Terry J. Smith; Lynn Wilson; Susan J. Kenwrick; Susan M. Forrest; Astrid Speer; Charles Coutelle; Kay E. Davies

doi:10.1093/nar/15.5.2167

Isolation of a conserved sequence deleted in duchenne muscular dystrophy patients

Terry J. Smith
, Lynn Wilson
, Susan J. Kenwrick
, Susan M. Forrest
, Astrid Speer
, Charles Coutelle
, Kay E. Davies

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

25 Citations (Scopus)

Abstract

We Have isolated a DNA sequence (HJP25) by subtraction-hybridisation which is deleted in a number of Duchenne muscular dystrophy (DMD) patients. HIP25 is conserved in evolution and hybridises to human fetal and adult muscle mRNA. HIP25 is absent in human fetal fibroblast mRNA. Physical mapping data localise this sequence within Xp21 between the breakpoints or Xiautosome translocations found in two females suffering from the disease. HIP25 is a candidate exon sequence for the basic defect in DMD boys deleted at this locus.

Original language	English
Pages (from-to)	2167-2174
Number of pages	8
Journal	Nucleic Acids Research
Volume	15
Issue number	5
DOIs	https://doi.org/10.1093/nar/15.5.2167
Publication status	Published - 15 Mar 1987
Externally published	Yes

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title = "Isolation of a conserved sequence deleted in duchenne muscular dystrophy patients",

abstract = "We Have isolated a DNA sequence (HJP25) by subtraction-hybridisation which is deleted in a number of Duchenne muscular dystrophy (DMD) patients. HIP25 is conserved in evolution and hybridises to human fetal and adult muscle mRNA. HIP25 is absent in human fetal fibroblast mRNA. Physical mapping data localise this sequence within Xp21 between the breakpoints or Xiautosome translocations found in two females suffering from the disease. HIP25 is a candidate exon sequence for the basic defect in DMD boys deleted at this locus.",

author = "Smith, \{Terry J.\} and Lynn Wilson and Kenwrick, \{Susan J.\} and Forrest, \{Susan M.\} and Astrid Speer and Charles Coutelle and Davies, \{Kay E.\}",

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AU - Smith, Terry J.

AU - Wilson, Lynn

AU - Kenwrick, Susan J.

AU - Forrest, Susan M.

AU - Speer, Astrid

AU - Coutelle, Charles

AU - Davies, Kay E.

PY - 1987/3/15

Y1 - 1987/3/15

N2 - We Have isolated a DNA sequence (HJP25) by subtraction-hybridisation which is deleted in a number of Duchenne muscular dystrophy (DMD) patients. HIP25 is conserved in evolution and hybridises to human fetal and adult muscle mRNA. HIP25 is absent in human fetal fibroblast mRNA. Physical mapping data localise this sequence within Xp21 between the breakpoints or Xiautosome translocations found in two females suffering from the disease. HIP25 is a candidate exon sequence for the basic defect in DMD boys deleted at this locus.

AB - We Have isolated a DNA sequence (HJP25) by subtraction-hybridisation which is deleted in a number of Duchenne muscular dystrophy (DMD) patients. HIP25 is conserved in evolution and hybridises to human fetal and adult muscle mRNA. HIP25 is absent in human fetal fibroblast mRNA. Physical mapping data localise this sequence within Xp21 between the breakpoints or Xiautosome translocations found in two females suffering from the disease. HIP25 is a candidate exon sequence for the basic defect in DMD boys deleted at this locus.

UR - https://www.scopus.com/pages/publications/0023139222

U2 - 10.1093/nar/15.5.2167

DO - 10.1093/nar/15.5.2167

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EP - 2174

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 5

ER -

Isolation of a conserved sequence deleted in duchenne muscular dystrophy patients

Abstract

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