Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea

Paul Murphy; Enda O'Connell; Olivier P. Thomas

doi:10.1016/j.tetlet.2017.02.037

Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea

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Abstract

A library of 864 extracts prepared from Irish marine organisms was screened in the search for novel antioxidants. Chemical investigation of the most promising extract obtained from the common lichen Lichina pygmaea led to the isolation of five resorcinol derivatives. An unusual urea moiety was found embedded in two of these compounds, pygmanilines A (1) and B (2) and their structures were confirmed by one-step chemical syntheses. (C) 2017 Elsevier Ltd. All rights reserved.

Original language	English (Ireland)
Pages (from-to)	1237-1239
Number of pages	3
Journal	Tetrahedron Letters
Volume	58
Issue number	12
DOIs	https://doi.org/10.1016/j.tetlet.2017.02.037
Publication status	Published - 1 Mar 2017

Keywords

Antioxidants
Lichen
Lichina pygmaea
Phenylurea

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Mahajan, N,Chadda, R,Calabro, K,Solanki, H,O'Connell, E,Murphy, PV,Thomas, OP

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10.1016/j.tetlet.2017.02.037

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abstract = "A library of 864 extracts prepared from Irish marine organisms was screened in the search for novel antioxidants. Chemical investigation of the most promising extract obtained from the common lichen Lichina pygmaea led to the isolation of five resorcinol derivatives. An unusual urea moiety was found embedded in two of these compounds, pygmanilines A (1) and B (2) and their structures were confirmed by one-step chemical syntheses. (C) 2017 Elsevier Ltd. All rights reserved.",

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PY - 2017/3/1

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N2 - A library of 864 extracts prepared from Irish marine organisms was screened in the search for novel antioxidants. Chemical investigation of the most promising extract obtained from the common lichen Lichina pygmaea led to the isolation of five resorcinol derivatives. An unusual urea moiety was found embedded in two of these compounds, pygmanilines A (1) and B (2) and their structures were confirmed by one-step chemical syntheses. (C) 2017 Elsevier Ltd. All rights reserved.

AB - A library of 864 extracts prepared from Irish marine organisms was screened in the search for novel antioxidants. Chemical investigation of the most promising extract obtained from the common lichen Lichina pygmaea led to the isolation of five resorcinol derivatives. An unusual urea moiety was found embedded in two of these compounds, pygmanilines A (1) and B (2) and their structures were confirmed by one-step chemical syntheses. (C) 2017 Elsevier Ltd. All rights reserved.

KW - Antioxidants

KW - Lichen

KW - Lichina pygmaea

KW - Phenylurea

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DO - 10.1016/j.tetlet.2017.02.037

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JF - Tetrahedron Letters

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ER -

Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea

Abstract

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

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