Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy

C. McCrae; L. Maxwell; R. Ceredig

doi:10.1038/icb.1988.23

Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy

C. McCrae, L. Maxwell, R. Ceredig

The John Curtin School of Medical Research

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

3 Citations (Scopus)

Abstract

The fate of internalized interleukin-2 receptors (IL-2R) on proliferating T cell blasts and Lyt-2^-/L3T4^- thymocytes was studied by immunogold electron microscopy. Immediately following labeling, IL-2R were found in coated pits and with time there was sequential appearance of gold particles in smooth vesicles or endosomes, multivesicular bodies and lysosomes. Thus the IL-2R appears to be a member of cell surface receptors internalized by endocytosis via coated pits.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Immunology and Cell Biology
Volume	66
Issue number	3
DOIs	https://doi.org/10.1038/icb.1988.23
Publication status	Published - 1988
Externally published	Yes

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10.1038/icb.1988.23

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title = "Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy",

abstract = "The fate of internalized interleukin-2 receptors (IL-2R) on proliferating T cell blasts and Lyt-2-/L3T4- thymocytes was studied by immunogold electron microscopy. Immediately following labeling, IL-2R were found in coated pits and with time there was sequential appearance of gold particles in smooth vesicles or endosomes, multivesicular bodies and lysosomes. Thus the IL-2R appears to be a member of cell surface receptors internalized by endocytosis via coated pits.",

author = "C. McCrae and L. Maxwell and R. Ceredig",

year = "1988",

doi = "10.1038/icb.1988.23",

language = "English",

volume = "66",

pages = "185--191",

journal = "Immunology and Cell Biology",

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publisher = "John Wiley \& Sons Inc.",

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T1 - Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy

AU - McCrae, C.

AU - Maxwell, L.

AU - Ceredig, R.

PY - 1988

Y1 - 1988

N2 - The fate of internalized interleukin-2 receptors (IL-2R) on proliferating T cell blasts and Lyt-2-/L3T4- thymocytes was studied by immunogold electron microscopy. Immediately following labeling, IL-2R were found in coated pits and with time there was sequential appearance of gold particles in smooth vesicles or endosomes, multivesicular bodies and lysosomes. Thus the IL-2R appears to be a member of cell surface receptors internalized by endocytosis via coated pits.

AB - The fate of internalized interleukin-2 receptors (IL-2R) on proliferating T cell blasts and Lyt-2-/L3T4- thymocytes was studied by immunogold electron microscopy. Immediately following labeling, IL-2R were found in coated pits and with time there was sequential appearance of gold particles in smooth vesicles or endosomes, multivesicular bodies and lysosomes. Thus the IL-2R appears to be a member of cell surface receptors internalized by endocytosis via coated pits.

UR - https://www.scopus.com/pages/publications/0023708589

U2 - 10.1038/icb.1988.23

DO - 10.1038/icb.1988.23

M3 - Article

SN - 0818-9641

VL - 66

SP - 185

EP - 191

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

IS - 3

ER -

Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy

Abstract

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