Interference: an alteRNAtive therapy following acute myocardial infarction

Timothy O'Brien; Abhay Shashikant Pandit; Gerard Wall

doi:10.1016/j.tips.2012.09.003

Interference: an alteRNAtive therapy following acute myocardial infarction

Timothy O'Brien, Abhay Shashikant Pandit, Gerard Wall

Research output: Other contribution (Published) › Other contribution

Abstract

A complex cascade of genomic and proteomic interactions follows myocardial infarction (MI) irrespective of the intervention employed. A potential pharmacological intervention gaining momentum is RNAi therapy. RNAi therapy has been successfully clinically used in the treatment of age-related macular degeneration and cancer, but its translation to the coronary care unit is lacking despite the existence of preclinical proof of concept. Here we review current RNAi approaches and tissue-specific delivery systems that exhibit candidacy as future pharmacological interventions following MI and considerations for improved non-viral delivery to the infarcted myocardium.

Original language	English (Ireland)
Media of output	Reviews
Publisher	ELSEVIER SCIENCE LONDON
Volume	33
ISBN (Print)	0165-6147
ISBN (Electronic)	0165-6147
DOIs	https://doi.org/10.1016/j.tips.2012.09.003
Publication status	Published - 1 Dec 2012

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10.1016/j.tips.2012.09.003

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title = "Interference: an alteRNAtive therapy following acute myocardial infarction",

abstract = "A complex cascade of genomic and proteomic interactions follows myocardial infarction (MI) irrespective of the intervention employed. A potential pharmacological intervention gaining momentum is RNAi therapy. RNAi therapy has been successfully clinically used in the treatment of age-related macular degeneration and cancer, but its translation to the coronary care unit is lacking despite the existence of preclinical proof of concept. Here we review current RNAi approaches and tissue-specific delivery systems that exhibit candidacy as future pharmacological interventions following MI and considerations for improved non-viral delivery to the infarcted myocardium.",

author = "Timothy O'Brien and Pandit, \{Abhay Shashikant\} and Gerard Wall",

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AU - O'Brien, Timothy

AU - Pandit, Abhay Shashikant

AU - Wall, Gerard

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N2 - A complex cascade of genomic and proteomic interactions follows myocardial infarction (MI) irrespective of the intervention employed. A potential pharmacological intervention gaining momentum is RNAi therapy. RNAi therapy has been successfully clinically used in the treatment of age-related macular degeneration and cancer, but its translation to the coronary care unit is lacking despite the existence of preclinical proof of concept. Here we review current RNAi approaches and tissue-specific delivery systems that exhibit candidacy as future pharmacological interventions following MI and considerations for improved non-viral delivery to the infarcted myocardium.

AB - A complex cascade of genomic and proteomic interactions follows myocardial infarction (MI) irrespective of the intervention employed. A potential pharmacological intervention gaining momentum is RNAi therapy. RNAi therapy has been successfully clinically used in the treatment of age-related macular degeneration and cancer, but its translation to the coronary care unit is lacking despite the existence of preclinical proof of concept. Here we review current RNAi approaches and tissue-specific delivery systems that exhibit candidacy as future pharmacological interventions following MI and considerations for improved non-viral delivery to the infarcted myocardium.

U2 - 10.1016/j.tips.2012.09.003

DO - 10.1016/j.tips.2012.09.003

M3 - Other contribution

SN - 0165-6147

VL - 33

PB - ELSEVIER SCIENCE LONDON

ER -

Interference: an alteRNAtive therapy following acute myocardial infarction

Abstract

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