TY - JOUR
T1 - Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
AU - Kravariti, Eugenia
AU - Toulopoulou, Timothea
AU - Mapua-Filbey, Francesca
AU - Schulze, Katja
AU - Walshe, Muriel
AU - Sham, Pak
AU - Murray, Robin M.
AU - McDonald, Colm
PY - 2006/2
Y1 - 2006/2
N2 - Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.
AB - Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.
UR - https://www.scopus.com/pages/publications/31644437610
U2 - 10.1192/bjp.bp.104.008177
DO - 10.1192/bjp.bp.104.008177
M3 - Article
SN - 0007-1250
VL - 188
SP - 186
EP - 187
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - FEB.
ER -