TY - JOUR
T1 - Integrated view of Vibrio cholerae in the Americas
AU - Domman, Daryl
AU - Quilici, Marie Laure
AU - Dorman, Matthew J.
AU - Njamkepo, Elisabeth
AU - Mutreja, Ankur
AU - Mather, Alison E.
AU - Delgado, Gabriella
AU - Morales-Espinosa, Rosario
AU - Grimont, Patrick A.D.
AU - Lizárraga-Partida, Marcial Leonardo
AU - Bouchier, Christiane
AU - Aanensen, David M.
AU - Kuri-Morales, Pablo
AU - Tarr, Cheryl L.
AU - Dougan, Gordon
AU - Parkhill, Julian
AU - Campos, Josefina
AU - Cravioto, Alejandro
AU - Weill, François Xavier
AU - Thomson, Nicholas R.
N1 - Publisher Copyright:
© 2017, American Association for the Advancement of Science. All rights reserved.
PY - 2017/11/10
Y1 - 2017/11/10
N2 - Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.
AB - Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.
UR - https://www.scopus.com/pages/publications/85033467796
U2 - 10.1126/science.aao2136
DO - 10.1126/science.aao2136
M3 - Article
SN - 0036-8075
VL - 358
SP - 789
EP - 793
JO - Science
JF - Science
IS - 6364
ER -
