Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation

Caroline M. Curtin; Gráinne M. Cunniffe; Frank G. Lyons; Kazuhisa Bessho; Glenn R. Dickson; Garry P. Duffy; Fergal J. O'Brien

doi:10.1002/adma.201103828

Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation

Caroline M. Curtin
, Gráinne M. Cunniffe
, Frank G. Lyons
, Kazuhisa Bessho
, Glenn R. Dickson
, Garry P. Duffy
, Fergal J. O'Brien

Royal College of Surgeons in Ireland
Trinity College Dublin
Kyoto University
School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

196 Citations (Scopus)

Abstract

The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

Original language	English
Pages (from-to)	749-754
Number of pages	6
Journal	Advanced Materials
Volume	24
Issue number	6
DOIs	https://doi.org/10.1002/adma.201103828
Publication status	Published - 7 Feb 2012
Externally published	Yes

Keywords

biomedical applications
biomineralization
bionanotechnology
composite materials
tissue engineering

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10.1002/adma.201103828

Cite this

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title = "Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation",

abstract = "The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.",

keywords = "biomedical applications, biomineralization, bionanotechnology, composite materials, tissue engineering",

author = "Curtin, \{Caroline M.\} and Cunniffe, \{Gr{\'a}inne M.\} and Lyons, \{Frank G.\} and Kazuhisa Bessho and Dickson, \{Glenn R.\} and Duffy, \{Garry P.\} and O'Brien, \{Fergal J.\}",

year = "2012",

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language = "English",

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T1 - Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation

AU - Curtin, Caroline M.

AU - Cunniffe, Gráinne M.

AU - Lyons, Frank G.

AU - Bessho, Kazuhisa

AU - Dickson, Glenn R.

AU - Duffy, Garry P.

AU - O'Brien, Fergal J.

PY - 2012/2/7

Y1 - 2012/2/7

N2 - The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

AB - The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

KW - biomedical applications

KW - biomineralization

KW - bionanotechnology

KW - composite materials

KW - tissue engineering

UR - https://www.scopus.com/pages/publications/84856480411

U2 - 10.1002/adma.201103828

DO - 10.1002/adma.201103828

M3 - Article

SN - 0935-9648

VL - 24

SP - 749

EP - 754

JO - Advanced Materials

JF - Advanced Materials

IS - 6

ER -

Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation

Abstract

Keywords

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