Abstract
Objective: The purpose of this study was to investigate the effects of leptin on human uterine contractility in vitro.Study design: Biopsies of human myometrium were obtained at elective cesarean section (n = 18). Dissected myometrial strips suspended under isometric conditions, undergoing spontaneous and oxytocin-induced contractions, were exposed to cumulative additions of leptin in the concentration range of 1 nmol L to 1 mu mol L. Control strips were run simultaneously. Integrals of contractile activity were measured using the PowerLab hardware unit and Chart v3.6 software.Results: Leptin exerted a potent and cumulative inhibitory effect on spontaneous and oxytocin-induced contractions compared to control strips. The mean maximal inhibition values were as follows: 46.794 + - 5.133% (n = 6; P .001) for spontaneous contractions and 42.323 + - 3.692% (n = 6; P .001) for oxytocin-induced contractions. There was an apparent reduction in both frequency and amplitude of contractions.Conclusion: This physiologic inhibitory effect of leptin on uterine contractility may play a role in the dysfunctional labor process associated with maternal obesity, and the resultant high cesarean section rates. (c) 2006 Mosby, Inc. All rights reserved.
| Original language | English (Ireland) |
|---|---|
| Number of pages | 6 |
| Journal | American Journal Of Obstetrics And Gynecology |
| Volume | 195 |
| DOIs | |
| Publication status | Published - 1 Aug 2006 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Moynihan, AT,Hehir, MP,Glavey, SV,Smith, TJ,Morrison, JJ
- Moynihan, AT;Hehir, MP;Glavey, SV;Smith, TJ;Morrison, JJ