Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

Conor J. Kearney; Clare Sheridan; Sean P. Cullen; Graham A. Tynan; Susan E. Logue; Inna S. Afonina; Domagoj Vucic; Ed C. Lavelle; Seamus J. Martin

doi:10.1074/jbc.M112.422410

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

Conor J. Kearney, Clare Sheridan, Sean P. Cullen, Graham A. Tynan, Susan E. Logue, Inna S. Afonina, Domagoj Vucic, Ed C. Lavelle, Seamus J. Martin

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

35 Citations (Scopus)

Abstract

Background: IAP antagonists sensitize toward apoptosis induced by TNF and other TNFR family ligands. Results: IAP antagonism exerted effects on spontaneous as well as TNF-induced cytokine and chemokine production. Conclusion: IAPs regulate spontaneous as well as TNF-induced cytokine/chemokine production. Significance: IAP antagonists modulate cytokine production as well as apoptosis, which could influence their utility as adjuncts to chemotherapy.

Original language	English
Pages (from-to)	4878-4890
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.422410
Publication status	Published - 15 Feb 2013
Externally published	Yes

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10.1074/jbc.M112.422410

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Kearney, C. J., Sheridan, C., Cullen, S. P., Tynan, G. A., Logue, S. E., Afonina, I. S., Vucic, D., Lavelle, E. C., & Martin, S. J. (2013). Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production. Journal of Biological Chemistry, 288(7), 4878-4890. https://doi.org/10.1074/jbc.M112.422410

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title = "Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production",

abstract = "Background: IAP antagonists sensitize toward apoptosis induced by TNF and other TNFR family ligands. Results: IAP antagonism exerted effects on spontaneous as well as TNF-induced cytokine and chemokine production. Conclusion: IAPs regulate spontaneous as well as TNF-induced cytokine/chemokine production. Significance: IAP antagonists modulate cytokine production as well as apoptosis, which could influence their utility as adjuncts to chemotherapy.",

author = "Kearney, {Conor J.} and Clare Sheridan and Cullen, {Sean P.} and Tynan, {Graham A.} and Logue, {Susan E.} and Afonina, {Inna S.} and Domagoj Vucic and Lavelle, {Ed C.} and Martin, {Seamus J.}",

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doi = "10.1074/jbc.M112.422410",

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Kearney, CJ, Sheridan, C, Cullen, SP, Tynan, GA, Logue, SE, Afonina, IS, Vucic, D, Lavelle, EC & Martin, SJ 2013, 'Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production', Journal of Biological Chemistry, vol. 288, no. 7, pp. 4878-4890. https://doi.org/10.1074/jbc.M112.422410

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production. / Kearney, Conor J.; Sheridan, Clare; Cullen, Sean P. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 7, 15.02.2013, p. 4878-4890.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

AU - Kearney, Conor J.

AU - Sheridan, Clare

AU - Cullen, Sean P.

AU - Tynan, Graham A.

AU - Logue, Susan E.

AU - Afonina, Inna S.

AU - Vucic, Domagoj

AU - Lavelle, Ed C.

AU - Martin, Seamus J.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: IAP antagonists sensitize toward apoptosis induced by TNF and other TNFR family ligands. Results: IAP antagonism exerted effects on spontaneous as well as TNF-induced cytokine and chemokine production. Conclusion: IAPs regulate spontaneous as well as TNF-induced cytokine/chemokine production. Significance: IAP antagonists modulate cytokine production as well as apoptosis, which could influence their utility as adjuncts to chemotherapy.

AB - Background: IAP antagonists sensitize toward apoptosis induced by TNF and other TNFR family ligands. Results: IAP antagonism exerted effects on spontaneous as well as TNF-induced cytokine and chemokine production. Conclusion: IAPs regulate spontaneous as well as TNF-induced cytokine/chemokine production. Significance: IAP antagonists modulate cytokine production as well as apoptosis, which could influence their utility as adjuncts to chemotherapy.

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DO - 10.1074/jbc.M112.422410

M3 - Article

SN - 0021-9258

VL - 288

SP - 4878

EP - 4890

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

Abstract

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