Influence of toxicants on neural cell adhesion moleculemediated neuroplasticity in the developing and adult animal: persistent effects of chronic perinatal low-level lead exposure

Keith J. Murphy; Gerard B. Fox; John Kelly; Ciaran M. Regan

doi:10.1016/0378-4274(95)03561-3

Influence of toxicants on neural cell adhesion moleculemediated neuroplasticity in the developing and adult animal: persistent effects of chronic perinatal low-level lead exposure

Keith J. Murphy
, Gerard B. Fox
, John Kelly
, Ciaran M. Regan

University College Dublin

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

6 Citations (Scopus)

Abstract

The expression of neuroplastic neural cell adhesion molecule (NCAM) polysialylated neurons in the dentate of juvenile (postnatal day 40) and adult (postnatal day 80) rats exposed to low-level lead during the early postnatal period has been investigated. At both ages, the number of polysialylated neurons was decreased significantly in lead-exposed animals when expressed per unit area but not total dentate area. This could be attributed to an increase in the number and intercellular spacing of granule cells in the dentate of the lead-exposed animals. These effects are related to NCAM polysialylation dysfunction perturbing early hippocampal neurogenesis.

Original language	English
Pages (from-to)	271-276
Number of pages	6
Journal	Toxicology Letters
Volume	82-83
Issue number	C
DOIs	https://doi.org/10.1016/0378-4274(95)03561-3
Publication status	Published - Dec 1995
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dentate
Learning
Polysialylation
Proliferation

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10.1016/0378-4274(95)03561-3

Cite this

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title = "Influence of toxicants on neural cell adhesion moleculemediated neuroplasticity in the developing and adult animal: persistent effects of chronic perinatal low-level lead exposure",

abstract = "The expression of neuroplastic neural cell adhesion molecule (NCAM) polysialylated neurons in the dentate of juvenile (postnatal day 40) and adult (postnatal day 80) rats exposed to low-level lead during the early postnatal period has been investigated. At both ages, the number of polysialylated neurons was decreased significantly in lead-exposed animals when expressed per unit area but not total dentate area. This could be attributed to an increase in the number and intercellular spacing of granule cells in the dentate of the lead-exposed animals. These effects are related to NCAM polysialylation dysfunction perturbing early hippocampal neurogenesis.",

keywords = "Dentate, Learning, Polysialylation, Proliferation",

author = "Murphy, \{Keith J.\} and Fox, \{Gerard B.\} and John Kelly and Regan, \{Ciaran M.\}",

year = "1995",

month = dec,

doi = "10.1016/0378-4274(95)03561-3",

language = "English",

volume = "82-83",

pages = "271--276",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier Ireland Ltd",

number = "C",

}

Influence of toxicants on neural cell adhesion moleculemediated neuroplasticity in the developing and adult animal: persistent effects of chronic perinatal low-level lead exposure. / Murphy, Keith J.; Fox, Gerard B.; Kelly, John et al.
In: Toxicology Letters, Vol. 82-83, No. C, 12.1995, p. 271-276.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Influence of toxicants on neural cell adhesion moleculemediated neuroplasticity in the developing and adult animal

T2 - persistent effects of chronic perinatal low-level lead exposure

AU - Murphy, Keith J.

AU - Fox, Gerard B.

AU - Kelly, John

AU - Regan, Ciaran M.

PY - 1995/12

Y1 - 1995/12

N2 - The expression of neuroplastic neural cell adhesion molecule (NCAM) polysialylated neurons in the dentate of juvenile (postnatal day 40) and adult (postnatal day 80) rats exposed to low-level lead during the early postnatal period has been investigated. At both ages, the number of polysialylated neurons was decreased significantly in lead-exposed animals when expressed per unit area but not total dentate area. This could be attributed to an increase in the number and intercellular spacing of granule cells in the dentate of the lead-exposed animals. These effects are related to NCAM polysialylation dysfunction perturbing early hippocampal neurogenesis.

AB - The expression of neuroplastic neural cell adhesion molecule (NCAM) polysialylated neurons in the dentate of juvenile (postnatal day 40) and adult (postnatal day 80) rats exposed to low-level lead during the early postnatal period has been investigated. At both ages, the number of polysialylated neurons was decreased significantly in lead-exposed animals when expressed per unit area but not total dentate area. This could be attributed to an increase in the number and intercellular spacing of granule cells in the dentate of the lead-exposed animals. These effects are related to NCAM polysialylation dysfunction perturbing early hippocampal neurogenesis.

KW - Dentate

KW - Learning

KW - Polysialylation

KW - Proliferation

UR - https://www.scopus.com/pages/publications/17644439548

U2 - 10.1016/0378-4274(95)03561-3

DO - 10.1016/0378-4274(95)03561-3

M3 - Article

C2 - 8597065

AN - SCOPUS:17644439548

SN - 0378-4274

VL - 82-83

SP - 271

EP - 276

JO - Toxicology Letters

JF - Toxicology Letters

IS - C

ER -

Influence of toxicants on neural cell adhesion moleculemediated neuroplasticity in the developing and adult animal: persistent effects of chronic perinatal low-level lead exposure

Abstract

UN SDGs

Keywords

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