Abstract
Normal aging is associated with accumulation of lipofuscin pigment in the retinal pigment epithelium (RPE). This may occur as a result of phagocytosis and incomplete degradation of oxidized photoreceptor outer segments (POS). This study was undertaken to determine whether phagocytosis of UV-irradiated POS (artificial lipofuscin) would increase expression in the RPE of various chemotactic and angiogenic cytokines.
| Original language | English (Ireland) |
|---|---|
| Number of pages | 8 |
| Journal | Mol Vis |
| Volume | 44 |
| Issue number | 4 |
| Publication status | Published - 1 Apr 2003 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Higgins GT, Wang JH, Dockery P, Cleary PE, Redmond HP