Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

Baofeng Feng; Jun Ma; Asiamah Ernest Amponsah; Ruiyun Guo; Desheng Kong; Jingjing He; Yawen Jiang; Wei Zhang; Zhanchi Zhang; Yongzhou Song; Sanbing Shen; Timothy O'Brien; Huixian Cui

doi:10.1016/j.scr.2020.101841

Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

Baofeng Feng
, Jun Ma
, Asiamah Ernest Amponsah
, Ruiyun Guo
, Desheng Kong
, Jingjing He
, Yawen Jiang
, Wei Zhang
, Zhanchi Zhang
, Yongzhou Song
, Sanbing Shen
, Timothy O'Brien
, Huixian Cui

Medicine

University of Galway
Hebei Research Center for Stem Cell Medical Translational Engineering
Hebei Medical University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS).

Original language	English
Article number	101841
Number of pages	0
Journal	Stem Cell Research
Volume	45
DOIs	https://doi.org/10.1016/j.scr.2020.101841
Publication status	Published - 1 May 2020

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Feng, BF;Ma, J;Amponsah, AE;Guo, RY;Kong, DS;He, JJ;Jiang, YW;Zhang, W;Zhang, ZC;Song, YZ;Shen, SB;O'Brien, T;Cui, HX

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10.1016/j.scr.2020.101841

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title = "Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient",

abstract = "Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS).",

author = "Baofeng Feng and Jun Ma and Amponsah, \{Asiamah Ernest\} and Ruiyun Guo and Desheng Kong and Jingjing He and Yawen Jiang and Wei Zhang and Zhanchi Zhang and Yongzhou Song and Sanbing Shen and Timothy O'Brien and Huixian Cui",

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year = "2020",

month = may,

day = "1",

doi = "10.1016/j.scr.2020.101841",

language = "English",

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journal = "Stem Cell Research",

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T1 - Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

AU - Feng, Baofeng

AU - Ma, Jun

AU - Amponsah, Asiamah Ernest

AU - Guo, Ruiyun

AU - Kong, Desheng

AU - He, Jingjing

AU - Jiang, Yawen

AU - Zhang, Wei

AU - Zhang, Zhanchi

AU - Song, Yongzhou

AU - Shen, Sanbing

AU - O'Brien, Timothy

AU - Cui, Huixian

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS).

AB - Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS).

UR - https://www.scopus.com/pages/publications/85084576072

U2 - 10.1016/j.scr.2020.101841

DO - 10.1016/j.scr.2020.101841

M3 - Article

SN - 1873-5061

VL - 45

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 101841

ER -

Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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