In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids

John Kelly; Michelle Roche; David P. Finn

doi:10.1016/j.jneuroim.2006.08.001

In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids

University of Galway

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62 Citations (Scopus)

Abstract

This study investigated cannabinoid receptor-mediated regulation of brain and peripheral cytokines in vivo. The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1 beta and TNF alpha in rat brain and IL-1 beta, TNF alpha, IL-6 and IFN gamma in plasma. The CB1 receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1 beta, but not TNF alpha. SR141716A or the CB2 receptor antagonist, SR144528, alone attenuated LPS-induced cytokine increases. LPS and or cannabinoids also reduced circulating lymphocyte numbers and increased corticosterone levels. These data provide evidence for modulation of pro-inflammatory cytokines in vivo by cannabinoid receptors and inform the development of cannabinoids for neuroinflammatory disorders. (c) 2006 Elsevier B.V. All rights reserved.

Original language	English (Ireland)
Pages (from-to)	57-67
Number of pages	11
Journal	Journal Of Neuroimmunology
Volume	181
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.08.001
Publication status	Published - 1 Dec 2006

Keywords

Corticosterone
HU210
IL-1β
SR141716A
SR144528
TNFα

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Roche, M,Diamond, M,Kelly, JP,Finn, DP
Roche, M;Diamond, M;Kelly, JP;Finn, DP

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10.1016/j.jneuroim.2006.08.001

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title = "In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids",

abstract = "This study investigated cannabinoid receptor-mediated regulation of brain and peripheral cytokines in vivo. The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1 beta and TNF alpha in rat brain and IL-1 beta, TNF alpha, IL-6 and IFN gamma in plasma. The CB1 receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1 beta, but not TNF alpha. SR141716A or the CB2 receptor antagonist, SR144528, alone attenuated LPS-induced cytokine increases. LPS and or cannabinoids also reduced circulating lymphocyte numbers and increased corticosterone levels. These data provide evidence for modulation of pro-inflammatory cytokines in vivo by cannabinoid receptors and inform the development of cannabinoids for neuroinflammatory disorders. (c) 2006 Elsevier B.V. All rights reserved.",

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AU - Finn, David P.

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AB - This study investigated cannabinoid receptor-mediated regulation of brain and peripheral cytokines in vivo. The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1 beta and TNF alpha in rat brain and IL-1 beta, TNF alpha, IL-6 and IFN gamma in plasma. The CB1 receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1 beta, but not TNF alpha. SR141716A or the CB2 receptor antagonist, SR144528, alone attenuated LPS-induced cytokine increases. LPS and or cannabinoids also reduced circulating lymphocyte numbers and increased corticosterone levels. These data provide evidence for modulation of pro-inflammatory cytokines in vivo by cannabinoid receptors and inform the development of cannabinoids for neuroinflammatory disorders. (c) 2006 Elsevier B.V. All rights reserved.

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KW - HU210

KW - IL-1β

KW - SR141716A

KW - SR144528

KW - TNFα

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In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids

Abstract

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

Access to Document

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