Immunity unmasks APOL1 in collapsing glomerulopathy

Bairbre A. McNicholas; Peter J. Nelson

doi:10.1038/ki.2014.325

Immunity unmasks APOL1 in collapsing glomerulopathy

Bairbre A. McNicholas
, Peter J. Nelson

Research output: Contribution to a Journal (Peer & Non Peer) › Comment/debate

6 Citations (Scopus)

Abstract

Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.

Original language	English
Pages (from-to)	270-272
Number of pages	3
Journal	Kidney International
Volume	87
Issue number	2
DOIs	https://doi.org/10.1038/ki.2014.325
Publication status	Published - 3 Feb 2015
Externally published	Yes

Keywords

cytokines
glomerulus
inflammation
podocyte
renal pathology
signaling

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10.1038/ki.2014.325

Cite this

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title = "Immunity unmasks APOL1 in collapsing glomerulopathy",

abstract = "Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.",

keywords = "cytokines, glomerulus, inflammation, podocyte, renal pathology, signaling",

author = "McNicholas, \{Bairbre A.\} and Nelson, \{Peter J.\}",

note = "Publisher Copyright: {\textcopyright} 2014 International Society of Nephrology.",

year = "2015",

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AU - McNicholas, Bairbre A.

AU - Nelson, Peter J.

PY - 2015/2/3

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N2 - Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.

AB - Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.

KW - cytokines

KW - glomerulus

KW - inflammation

KW - podocyte

KW - renal pathology

KW - signaling

UR - https://www.scopus.com/pages/publications/84922118801

U2 - 10.1038/ki.2014.325

DO - 10.1038/ki.2014.325

M3 - Comment/debate

C2 - 25635718

AN - SCOPUS:84922118801

SN - 0085-2538

VL - 87

SP - 270

EP - 272

JO - Kidney International

JF - Kidney International

IS - 2

ER -

Immunity unmasks APOL1 in collapsing glomerulopathy

Abstract

Keywords

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