Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library

Paul V. Murphy; Nigel Pitt; Alan O'Brien; Philomena M. Enright; Amanda Dunne; Stephen J. Wilson; Rhona M. Duane; Kathy M. O'Boyle

doi:10.1016/S0960-894X(02)00700-X

Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library

Paul V. Murphy
, Nigel Pitt
, Alan O'Brien
, Philomena M. Enright
, Amanda Dunne
, Stephen J. Wilson
, Rhona M. Duane
, Kathy M. O'Boyle

University College Dublin

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

24 Citations (Scopus)

Abstract

Inhibitors of FGF-2 binding to a heparin-albumin conjugate were identified by ELISA from a library of glucuronic acid derivatives. These compounds were also inhibitors of endothelial cell survival that is dependant on FGF-2 and heparin or heparan sulfate proteoglycans. The results indicate that these bioactive compounds may prove useful as lead structures for the further development of pharmaceutical agents capable of modulating biological activity of FGF-2.

Original language	English
Pages (from-to)	3287-3290
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(02)00700-X
Publication status	Published - 18 Nov 2002
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0960-894X(02)00700-X

Cite this

Murphy, P. V., Pitt, N., O'Brien, A., Enright, P. M., Dunne, A., Wilson, S. J., Duane, R. M., & O'Boyle, K. M. (2002). Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library. Bioorganic and Medicinal Chemistry Letters, 12(22), 3287-3290. https://doi.org/10.1016/S0960-894X(02)00700-X

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title = "Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library",

abstract = "Inhibitors of FGF-2 binding to a heparin-albumin conjugate were identified by ELISA from a library of glucuronic acid derivatives. These compounds were also inhibitors of endothelial cell survival that is dependant on FGF-2 and heparin or heparan sulfate proteoglycans. The results indicate that these bioactive compounds may prove useful as lead structures for the further development of pharmaceutical agents capable of modulating biological activity of FGF-2.",

author = "Murphy, \{Paul V.\} and Nigel Pitt and Alan O'Brien and Enright, \{Philomena M.\} and Amanda Dunne and Wilson, \{Stephen J.\} and Duane, \{Rhona M.\} and O'Boyle, \{Kathy M.\}",

year = "2002",

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day = "18",

doi = "10.1016/S0960-894X(02)00700-X",

language = "English",

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pages = "3287--3290",

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Murphy, PV, Pitt, N, O'Brien, A, Enright, PM, Dunne, A, Wilson, SJ, Duane, RM & O'Boyle, KM 2002, 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 22, pp. 3287-3290. https://doi.org/10.1016/S0960-894X(02)00700-X

Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library. / Murphy, Paul V.; Pitt, Nigel; O'Brien, Alan et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 22, 18.11.2002, p. 3287-3290.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library

AU - Murphy, Paul V.

AU - Pitt, Nigel

AU - O'Brien, Alan

AU - Enright, Philomena M.

AU - Dunne, Amanda

AU - Wilson, Stephen J.

AU - Duane, Rhona M.

AU - O'Boyle, Kathy M.

PY - 2002/11/18

Y1 - 2002/11/18

N2 - Inhibitors of FGF-2 binding to a heparin-albumin conjugate were identified by ELISA from a library of glucuronic acid derivatives. These compounds were also inhibitors of endothelial cell survival that is dependant on FGF-2 and heparin or heparan sulfate proteoglycans. The results indicate that these bioactive compounds may prove useful as lead structures for the further development of pharmaceutical agents capable of modulating biological activity of FGF-2.

AB - Inhibitors of FGF-2 binding to a heparin-albumin conjugate were identified by ELISA from a library of glucuronic acid derivatives. These compounds were also inhibitors of endothelial cell survival that is dependant on FGF-2 and heparin or heparan sulfate proteoglycans. The results indicate that these bioactive compounds may prove useful as lead structures for the further development of pharmaceutical agents capable of modulating biological activity of FGF-2.

UR - https://www.scopus.com/pages/publications/0037131770

U2 - 10.1016/S0960-894X(02)00700-X

DO - 10.1016/S0960-894X(02)00700-X

M3 - Article

SN - 0960-894X

VL - 12

SP - 3287

EP - 3290

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library

Abstract

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