Hypothalamo-pituitary-adrenal axis activation by administration of cyanamide: A potent inhibitor of aldehyde dehydrogenase

H. Kinoshita; M. S. Harbuz; D. S. Jessop; D. P. Finn; S. Ameno; K. Ameno; T. Kubota; I. Ijiri

doi:10.1016/S0379-0738(00)00212-7

Hypothalamo-pituitary-adrenal axis activation by administration of cyanamide: A potent inhibitor of aldehyde dehydrogenase

H. Kinoshita
, M. S. Harbuz
, D. S. Jessop
, D. P. Finn
, S. Ameno
, K. Ameno
, T. Kubota
, I. Ijiri

University of Bristol
Kagawa Medical University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

5 Citations (Scopus)

Abstract

In this report, we investigated the effects of cyanamide (a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3)) on hypothalamo-pituitary adrenal (HPA)-axis using in situ hybridization histochemistry and radioimmunoassay. Cyanamide administration resulted in a dose-dependent increase in plasma corticosterone concentrations, significant increases in not only corticotrophin releasing factor (CRF) mRNA, but also arginine vasopressin (AVP) mRNA in the paraventricular nucleus (PVN) and proopiomelanocortin (POMC) mRNA in the anterior pituitary. These results suggest that cyanamide is able to activate the HPA axis at all levels of the axis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	397-402
Number of pages	6
Journal	Forensic Science International
Volume	113
Issue number	1-3
DOIs	https://doi.org/10.1016/S0379-0738(00)00212-7
Publication status	Published - 11 Sep 2000
Externally published	Yes

Keywords

Arginine vasopressin mRNA
Corticosterone
Corticotrophin releasing factor mRNA
Cyanamide
Hypothalamo-pituitary-adrenal axis
Proopiomelanocortin mRNA

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10.1016/S0379-0738(00)00212-7

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@article{40611e401001410fa9521219d6b14bf3,

title = "Hypothalamo-pituitary-adrenal axis activation by administration of cyanamide: A potent inhibitor of aldehyde dehydrogenase",

abstract = "In this report, we investigated the effects of cyanamide (a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3)) on hypothalamo-pituitary adrenal (HPA)-axis using in situ hybridization histochemistry and radioimmunoassay. Cyanamide administration resulted in a dose-dependent increase in plasma corticosterone concentrations, significant increases in not only corticotrophin releasing factor (CRF) mRNA, but also arginine vasopressin (AVP) mRNA in the paraventricular nucleus (PVN) and proopiomelanocortin (POMC) mRNA in the anterior pituitary. These results suggest that cyanamide is able to activate the HPA axis at all levels of the axis. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Arginine vasopressin mRNA, Corticosterone, Corticotrophin releasing factor mRNA, Cyanamide, Hypothalamo-pituitary-adrenal axis, Proopiomelanocortin mRNA",

author = "H. Kinoshita and Harbuz, \{M. S.\} and Jessop, \{D. S.\} and Finn, \{D. P.\} and S. Ameno and K. Ameno and T. Kubota and I. Ijiri",

year = "2000",

month = sep,

day = "11",

doi = "10.1016/S0379-0738(00)00212-7",

language = "English",

volume = "113",

pages = "397--402",

journal = "Forensic Science International",

issn = "0379-0738",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Hypothalamo-pituitary-adrenal axis activation by administration of cyanamide

T2 - A potent inhibitor of aldehyde dehydrogenase

AU - Kinoshita, H.

AU - Harbuz, M. S.

AU - Jessop, D. S.

AU - Finn, D. P.

AU - Ameno, S.

AU - Ameno, K.

AU - Kubota, T.

AU - Ijiri, I.

PY - 2000/9/11

Y1 - 2000/9/11

N2 - In this report, we investigated the effects of cyanamide (a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3)) on hypothalamo-pituitary adrenal (HPA)-axis using in situ hybridization histochemistry and radioimmunoassay. Cyanamide administration resulted in a dose-dependent increase in plasma corticosterone concentrations, significant increases in not only corticotrophin releasing factor (CRF) mRNA, but also arginine vasopressin (AVP) mRNA in the paraventricular nucleus (PVN) and proopiomelanocortin (POMC) mRNA in the anterior pituitary. These results suggest that cyanamide is able to activate the HPA axis at all levels of the axis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - In this report, we investigated the effects of cyanamide (a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3)) on hypothalamo-pituitary adrenal (HPA)-axis using in situ hybridization histochemistry and radioimmunoassay. Cyanamide administration resulted in a dose-dependent increase in plasma corticosterone concentrations, significant increases in not only corticotrophin releasing factor (CRF) mRNA, but also arginine vasopressin (AVP) mRNA in the paraventricular nucleus (PVN) and proopiomelanocortin (POMC) mRNA in the anterior pituitary. These results suggest that cyanamide is able to activate the HPA axis at all levels of the axis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Arginine vasopressin mRNA

KW - Corticosterone

KW - Corticotrophin releasing factor mRNA

KW - Cyanamide

KW - Hypothalamo-pituitary-adrenal axis

KW - Proopiomelanocortin mRNA

UR - https://www.scopus.com/pages/publications/0343006749

U2 - 10.1016/S0379-0738(00)00212-7

DO - 10.1016/S0379-0738(00)00212-7

M3 - Article

SN - 0379-0738

VL - 113

SP - 397

EP - 402

JO - Forensic Science International

JF - Forensic Science International

IS - 1-3

ER -

Hypothalamo-pituitary-adrenal axis activation by administration of cyanamide: A potent inhibitor of aldehyde dehydrogenase

Abstract

Keywords

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