Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia.

Brendan Higgins; John Laffey

doi:10.1097/ALN.0b013e3181895fb7

Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia.

Anaesthesia

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

67 Citations (Scopus)

Abstract

Hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. The effects of hypercapnic acidosis in the setting of established pulmonary sepsis are not known. The authors investigated whether hypercapnic acidosis -- induced by adding carbon dioxide to inspired gas -- would be beneficial or deleterious in established Escherichia coli pneumonia in an in vivo model, in the presence and absence of antibiotic therapy.

Original language	English (Ireland)
Pages (from-to)	837-848
Number of pages	12
Journal	Anesthesiology
Volume	109
Issue number	5
DOIs	https://doi.org/10.1097/ALN.0b013e3181895fb7
Publication status	Published - 1 Nov 2008

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Chonghaile MN, Higgins BD, Costello J, Laffey JG

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/ALN.0b013e3181895fb7

Cite this

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title = "Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia.",

abstract = "Hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. The effects of hypercapnic acidosis in the setting of established pulmonary sepsis are not known. The authors investigated whether hypercapnic acidosis -- induced by adding carbon dioxide to inspired gas -- would be beneficial or deleterious in established Escherichia coli pneumonia in an in vivo model, in the presence and absence of antibiotic therapy.",

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AB - Hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. The effects of hypercapnic acidosis in the setting of established pulmonary sepsis are not known. The authors investigated whether hypercapnic acidosis -- induced by adding carbon dioxide to inspired gas -- would be beneficial or deleterious in established Escherichia coli pneumonia in an in vivo model, in the presence and absence of antibiotic therapy.

UR - https://www.scopus.com/pages/publications/56149124268

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Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia.

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

UN SDGs

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