@inbook{c1aa69a8b5db4ac9ab18a832307542fa,
title = "HPLC purification of adenoviral vectors",
abstract = "Adenoviruses are attractive vectors for gene therapy where short-term transgene expression is required. In order to meet the clinical requirements of adenovirus for use beyond the laboratory, advanced methods are required for the purification and quantitation of recombinant adenoviral vectors (rAd). Chromatographic systems offer the advantages of linear scalability and reproducibility, and this method describes a laboratory-scale process based on liquid chromatography, which can be technically transferred and readily scaled-up according to the demands of the laboratory or clinic in which it will be used.",
keywords = "Adenovirus, Anion exchange, Chromatography, Gel filtration, Gene therapy vectors",
author = "Marc Eglon and Barry McGrath and Timothy O'Brien",
year = "2010",
doi = "10.1007/978-1-60761-411-1_28",
language = "English",
isbn = "9781607614104",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "395--408",
booktitle = "Advanced Protocols in Oxidative Stress II",
}