Homologous DNA recombination in vertebrate cells

Eiichiro Sonoda; Minoru Takata; Yukiko M. Yamashita; Ciaran Morrison; Shunichi Takeda

doi:10.1073/pnas.111006398

Homologous DNA recombination in vertebrate cells

Eiichiro Sonoda
, Minoru Takata
, Yukiko M. Yamashita
, Ciaran Morrison
, Shunichi Takeda

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

139 Citations (Scopus)

Abstract

The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.

Original language	English
Pages (from-to)	8388-8394
Number of pages	7
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	98
Issue number	15
DOIs	https://doi.org/10.1073/pnas.111006398
Publication status	Published - 17 Jul 2001
Externally published	Yes

Keywords

Double-strand break repair
DT40
Rad 51 family
Reverse genetic study

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10.1073/pnas.111006398

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author = "Eiichiro Sonoda and Minoru Takata and Yamashita, \{Yukiko M.\} and Ciaran Morrison and Shunichi Takeda",

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AU - Sonoda, Eiichiro

AU - Takata, Minoru

AU - Yamashita, Yukiko M.

AU - Morrison, Ciaran

AU - Takeda, Shunichi

PY - 2001/7/17

Y1 - 2001/7/17

N2 - The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.

AB - The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.

KW - Double-strand break repair

KW - DT40

KW - Rad 51 family

KW - Reverse genetic study

UR - https://www.scopus.com/pages/publications/0035902467

U2 - 10.1073/pnas.111006398

DO - 10.1073/pnas.111006398

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 15

ER -

Homologous DNA recombination in vertebrate cells

Abstract

Keywords

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