HLA class II frequencies in celiac disease patients in the West of Ireland

David A. Savage; Derek Middleton; Fionnaala Trainor; Alison Taylor; Marion Carson; Fiona M. Stevens; Ciaran F. McCarthy

doi:10.1016/0198-8859(92)90084-Z

HLA class II frequencies in celiac disease patients in the West of Ireland

David A. Savage
, Derek Middleton
, Fionnaala Trainor
, Alison Taylor
, Marion Carson
, Fiona M. Stevens
, Ciaran F. McCarthy

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

4 Citations (Scopus)

Abstract

Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Human Immunology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(92)90084-Z
Publication status	Published - May 1992

Keywords

CD celiac disease PCR polymerase chain reaction RFLP restriction fragment length polymorphism RR relative risk SSO sequence-specific oligonucleotide

Access to Document

10.1016/0198-8859(92)90084-Z

Cite this

@article{ba8be3ab93ac4bd1846b6c0ce0fcaf53,

title = "HLA class II frequencies in celiac disease patients in the West of Ireland",

abstract = "Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).",

keywords = "CD celiac disease PCR polymerase chain reaction RFLP restriction fragment length polymorphism RR relative risk SSO sequence-specific oligonucleotide",

author = "Savage, \{David A.\} and Derek Middleton and Fionnaala Trainor and Alison Taylor and Marion Carson and Stevens, \{Fiona M.\} and McCarthy, \{Ciaran F.\}",

year = "1992",

month = may,

doi = "10.1016/0198-8859(92)90084-Z",

language = "English",

volume = "34",

pages = "47--52",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - HLA class II frequencies in celiac disease patients in the West of Ireland

AU - Savage, David A.

AU - Middleton, Derek

AU - Trainor, Fionnaala

AU - Taylor, Alison

AU - Carson, Marion

AU - Stevens, Fiona M.

AU - McCarthy, Ciaran F.

PY - 1992/5

Y1 - 1992/5

N2 - Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).

AB - Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).

KW - CD celiac disease PCR polymerase chain reaction RFLP restriction fragment length polymorphism RR relative risk SSO sequence-specific oligonucleotide

UR - https://www.scopus.com/pages/publications/0026657988

U2 - 10.1016/0198-8859(92)90084-Z

DO - 10.1016/0198-8859(92)90084-Z

M3 - Article

C2 - 1356956

AN - SCOPUS:0026657988

SN - 0198-8859

VL - 34

SP - 47

EP - 52

JO - Human Immunology

JF - Human Immunology

IS - 1

ER -

HLA class II frequencies in celiac disease patients in the West of Ireland

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this