HLA class II frequencies in celiac disease patients in the West of Ireland

David A. Savage; Derek Middleton; Fionnaala Trainor; Alison Taylor; Marion Carson; Fiona M. Stevens; Ciaran F. McCarthy

doi:10.1016/0198-8859(92)90084-Z

HLA class II frequencies in celiac disease patients in the West of Ireland

David A. Savage, Derek Middleton, Fionnaala Trainor, Alison Taylor, Marion Carson, Fiona M. Stevens, Ciaran F. McCarthy

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

4 Citations (Scopus)

Abstract

Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Human Immunology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(92)90084-Z
Publication status	Published - May 1992

Keywords

CD celiac disease PCR polymerase chain reaction RFLP restriction fragment length polymorphism RR relative risk SSO sequence-specific oligonucleotide

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title = "HLA class II frequencies in celiac disease patients in the West of Ireland",

abstract = "Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).",

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AU - Savage, David A.

AU - Middleton, Derek

AU - Trainor, Fionnaala

AU - Taylor, Alison

AU - Carson, Marion

AU - Stevens, Fiona M.

AU - McCarthy, Ciaran F.

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AB - Restriction fragment length polymorphism analysis, using a single restriction enzyme TaqI-multiple-probe system for HLA-DRB1-DQB1 and -DQA1, was used to determine HLA-DR and -DQ frequencies in 56 unrelated celiac patients and 47 unrelated controls from the west of Ireland. In addition, HLA-DPB1 allelic frequencies were determined in the same grouo of patients and controls by using the technique of enzymatic DNA amplification of the polymorphic second exon of HLA-DPB1 genes in conjunction with sequence-specific oligonucleotide probing. The results suggest that HLA-DQ rather than HLA-DR is more important in conferring susceptibility to celiac disease. Furthermore, no association between HLA-DP and celiac disease was found in this study. Human Immunology 34, 47-52 (1992).

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HLA class II frequencies in celiac disease patients in the West of Ireland

Abstract

Keywords

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