Histone H2A/H2B Dimer Exchange by ATP-Dependent Chromatin Remodeling Activities

Michael Bruno; Andrew Flaus; Chris Stockdale; Chantal Rencurel; Helder Ferreira; Tom Owen-Hughes

doi:10.1016/S1097-2765(03)00499-4

Histone H2A/H2B Dimer Exchange by ATP-Dependent Chromatin Remodeling Activities

Michael Bruno, Andrew Flaus, Chris Stockdale, Chantal Rencurel, Helder Ferreira, Tom Owen-Hughes

University of Dundee

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

166 Citations (Scopus)

Abstract

ATP-dependent chromatin remodeling activities function to manipulate chromatin structure during gene regulation. One of the ways in which they do this is by altering the positions of nucleosomes along DNA. Here we provide support for the ability of these complexes to move nucleosomes into positions in which DNA is unraveled from one edge. This is expected to result in the loss of histone-DNA contacts that are important for retention of one H2A/H2B dimer within the nucleosome. Consistent with this we find that several chromatin remodeling complexes are capable of catalyzing the exchange of H2A/H2B dimers between chromatin fragments in an ATP-dependent reaction. This provides eukaryotes with additional means by which they may manipulate chromatin structure.

Original language	English
Pages (from-to)	1599-1606
Number of pages	8
Journal	Molecular Cell
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S1097-2765(03)00499-4
Publication status	Published - Dec 2003
Externally published	Yes

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title = "Histone H2A/H2B Dimer Exchange by ATP-Dependent Chromatin Remodeling Activities",

abstract = "ATP-dependent chromatin remodeling activities function to manipulate chromatin structure during gene regulation. One of the ways in which they do this is by altering the positions of nucleosomes along DNA. Here we provide support for the ability of these complexes to move nucleosomes into positions in which DNA is unraveled from one edge. This is expected to result in the loss of histone-DNA contacts that are important for retention of one H2A/H2B dimer within the nucleosome. Consistent with this we find that several chromatin remodeling complexes are capable of catalyzing the exchange of H2A/H2B dimers between chromatin fragments in an ATP-dependent reaction. This provides eukaryotes with additional means by which they may manipulate chromatin structure.",

author = "Michael Bruno and Andrew Flaus and Chris Stockdale and Chantal Rencurel and Helder Ferreira and Tom Owen-Hughes",

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AU - Bruno, Michael

AU - Flaus, Andrew

AU - Stockdale, Chris

AU - Rencurel, Chantal

AU - Ferreira, Helder

AU - Owen-Hughes, Tom

PY - 2003/12

Y1 - 2003/12

N2 - ATP-dependent chromatin remodeling activities function to manipulate chromatin structure during gene regulation. One of the ways in which they do this is by altering the positions of nucleosomes along DNA. Here we provide support for the ability of these complexes to move nucleosomes into positions in which DNA is unraveled from one edge. This is expected to result in the loss of histone-DNA contacts that are important for retention of one H2A/H2B dimer within the nucleosome. Consistent with this we find that several chromatin remodeling complexes are capable of catalyzing the exchange of H2A/H2B dimers between chromatin fragments in an ATP-dependent reaction. This provides eukaryotes with additional means by which they may manipulate chromatin structure.

AB - ATP-dependent chromatin remodeling activities function to manipulate chromatin structure during gene regulation. One of the ways in which they do this is by altering the positions of nucleosomes along DNA. Here we provide support for the ability of these complexes to move nucleosomes into positions in which DNA is unraveled from one edge. This is expected to result in the loss of histone-DNA contacts that are important for retention of one H2A/H2B dimer within the nucleosome. Consistent with this we find that several chromatin remodeling complexes are capable of catalyzing the exchange of H2A/H2B dimers between chromatin fragments in an ATP-dependent reaction. This provides eukaryotes with additional means by which they may manipulate chromatin structure.

UR - https://www.scopus.com/pages/publications/0347539781

U2 - 10.1016/S1097-2765(03)00499-4

DO - 10.1016/S1097-2765(03)00499-4

M3 - Article

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VL - 12

SP - 1599

EP - 1606

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

Histone H2A/H2B Dimer Exchange by ATP-Dependent Chromatin Remodeling Activities

Abstract

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