Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s

Grace P. McCormack; Judith R. Glynn; Amelia C. Crampin; Felix Sibande; Dominic Mulawa; Paul E.M. Fine; Jonathan P. Clewley

doi:10.1089/088922203765551782

Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s

Grace P. McCormack, Judith R. Glynn, Amelia C. Crampin, Felix Sibande, Dominic Mulawa, Paul E.M. Fine, Jonathan P. Clewley

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

2 Citations (Scopus)

Abstract

Six divergent HIV-1 partial env and gag genome sequences have been characterized in five subjects in Malawi, from whom blood spot samples were collected between 1982 and 1989, at the time that the AIDS epidemic there was starting. These sequences could not be classified with any of the recognized subtypes or circulating recombinant forms of HIV-1. They showed no consistent and/or supported associations with other subtypes by either env or gag gene phylogenetic analysis. Their genetic distances from defined subtypes suggest that they may be diverse subsubtype C viruses or, alternatively, that they may have mosaic genomes. Bootscanning analyses are consistent with their being mosaic viruses. These sequences highlight early HIV-1 diversity in a population otherwise dominated by subtype C.

Original language	English
Pages (from-to)	441-445
Number of pages	5
Journal	AIDS Research and Human Retroviruses
Volume	19
Issue number	5
DOIs	https://doi.org/10.1089/088922203765551782
Publication status	Published - 1 May 2003
Externally published	Yes

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title = "Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s",

abstract = "Six divergent HIV-1 partial env and gag genome sequences have been characterized in five subjects in Malawi, from whom blood spot samples were collected between 1982 and 1989, at the time that the AIDS epidemic there was starting. These sequences could not be classified with any of the recognized subtypes or circulating recombinant forms of HIV-1. They showed no consistent and/or supported associations with other subtypes by either env or gag gene phylogenetic analysis. Their genetic distances from defined subtypes suggest that they may be diverse subsubtype C viruses or, alternatively, that they may have mosaic genomes. Bootscanning analyses are consistent with their being mosaic viruses. These sequences highlight early HIV-1 diversity in a population otherwise dominated by subtype C.",

author = "McCormack, \{Grace P.\} and Glynn, \{Judith R.\} and Crampin, \{Amelia C.\} and Felix Sibande and Dominic Mulawa and Fine, \{Paul E.M.\} and Clewley, \{Jonathan P.\}",

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T1 - Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s

AU - McCormack, Grace P.

AU - Glynn, Judith R.

AU - Crampin, Amelia C.

AU - Sibande, Felix

AU - Mulawa, Dominic

AU - Fine, Paul E.M.

AU - Clewley, Jonathan P.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Six divergent HIV-1 partial env and gag genome sequences have been characterized in five subjects in Malawi, from whom blood spot samples were collected between 1982 and 1989, at the time that the AIDS epidemic there was starting. These sequences could not be classified with any of the recognized subtypes or circulating recombinant forms of HIV-1. They showed no consistent and/or supported associations with other subtypes by either env or gag gene phylogenetic analysis. Their genetic distances from defined subtypes suggest that they may be diverse subsubtype C viruses or, alternatively, that they may have mosaic genomes. Bootscanning analyses are consistent with their being mosaic viruses. These sequences highlight early HIV-1 diversity in a population otherwise dominated by subtype C.

AB - Six divergent HIV-1 partial env and gag genome sequences have been characterized in five subjects in Malawi, from whom blood spot samples were collected between 1982 and 1989, at the time that the AIDS epidemic there was starting. These sequences could not be classified with any of the recognized subtypes or circulating recombinant forms of HIV-1. They showed no consistent and/or supported associations with other subtypes by either env or gag gene phylogenetic analysis. Their genetic distances from defined subtypes suggest that they may be diverse subsubtype C viruses or, alternatively, that they may have mosaic genomes. Bootscanning analyses are consistent with their being mosaic viruses. These sequences highlight early HIV-1 diversity in a population otherwise dominated by subtype C.

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DO - 10.1089/088922203765551782

M3 - Article

SN - 0889-2229

VL - 19

SP - 441

EP - 445

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

IS - 5

ER -

Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s

Abstract

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