Abstract
Terminal complement component deficiency predisposes to meningococcal infection and is inherited in an autosomal co-dominant manner. An Irish family is described, in which 2 of 3 brothers had recurrent meningococcal infection. A novel screening assay was used to investigate for terminal complement deficiency and the 2 affected brothers were found to be completely deficient in the seventh component of complement (C7). Enzyme-linked immunosorbent assay for C7 revealed lower than normal levels in the remaining brother and parents. C7 M N protein polymorphism allotyping, used to investigate the segregation of the C7 deficiency genes, showed that the apparently complement sufficient brother was heterozygous C7 deficient and a carrier of one of the deficiency genes. Complement screening should be carried out in any individual suffering recurrent meningococcal infection or infection with an uncommon meningococcal serogroup. Identification of complement deficient patients allows the implementation of strategies to prevent recurrent infection.
| Original language | English (Ireland) |
|---|---|
| Number of pages | 7 |
| Journal | Epidemiology And Infection |
| Volume | 113 |
| Publication status | Published - 1 Oct 1994 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- EGAN, LJ,ORREN, A,DOHERTY, J,WURZNER, R,MCCARTHY, CF
Fingerprint
Dive into the research topics of 'HEREDITARY-DEFICIENCY OF THE 7TH COMPONENT OF COMPLEMENT AND RECURRENT MENINGOCOCCAL INFECTION - INVESTIGATIONS OF AN IRISH FAMILY USING A NOVEL HEMOLYTIC SCREENING ASSAY FOR COMPLEMENT ACTIVITY AND C7 M N ALLOTYPING'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver