Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population

A. W. Ryan; J. M. Thornton; K. Brophy; J. S. Daly; C. O'Morain; R. M. McLoughlin; N. P. Kennedy; M. Abuzakouk; F. M. Stevens; C. Feighery; D. Kelleher; R. McManus

doi:10.1111/j.1399-0039.2004.00251.x

Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population

A. W. Ryan, J. M. Thornton, K. Brophy, J. S. Daly, C. O'Morain, R. M. McLoughlin, N. P. Kennedy, M. Abuzakouk, F. M. Stevens, C. Feighery, D. Kelleher, R. McManus

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

14 Citations (Scopus)

Abstract

In addition to the well-established association of coeliac disease (CD) with HLA-DQ (6p21) and possibly CTLA4 (2q33), there is considerable evidence for a susceptibility locus on chromosome 5q, which contains many potential candidates for inflammatory disease, including a cluster of cytokine genes in 5q31. CD cases and controls were genotyped for four single- nucleotide polymorphism (SNP) markers that together characterize >90% of the haplotype variation at the IBD5 locus encoding, among others, the SLC22A4 gene. IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. Haplotype frequencies do not differ significantly between CD cases and controls in the Irish population, and therefore the chromosome 5 CD susceptibility locus most likely lies elsewhere on 5q.

Original language	English
Pages (from-to)	195-198
Number of pages	4
Journal	Tissue Antigens
Volume	64
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-0039.2004.00251.x
Publication status	Published - Aug 2004

Keywords

5q31
Autoimmunity
Coeliac disease
Gluten sensitivity
IBD5
SLC22A4

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10.1111/j.1399-0039.2004.00251.x

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title = "Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population",

abstract = "In addition to the well-established association of coeliac disease (CD) with HLA-DQ (6p21) and possibly CTLA4 (2q33), there is considerable evidence for a susceptibility locus on chromosome 5q, which contains many potential candidates for inflammatory disease, including a cluster of cytokine genes in 5q31. CD cases and controls were genotyped for four single- nucleotide polymorphism (SNP) markers that together characterize >90% of the haplotype variation at the IBD5 locus encoding, among others, the SLC22A4 gene. IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. Haplotype frequencies do not differ significantly between CD cases and controls in the Irish population, and therefore the chromosome 5 CD susceptibility locus most likely lies elsewhere on 5q.",

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author = "Ryan, {A. W.} and Thornton, {J. M.} and K. Brophy and Daly, {J. S.} and C. O'Morain and McLoughlin, {R. M.} and Kennedy, {N. P.} and M. Abuzakouk and Stevens, {F. M.} and C. Feighery and D. Kelleher and R. McManus",

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AU - Ryan, A. W.

AU - Thornton, J. M.

AU - Brophy, K.

AU - Daly, J. S.

AU - O'Morain, C.

AU - McLoughlin, R. M.

AU - Kennedy, N. P.

AU - Abuzakouk, M.

AU - Stevens, F. M.

AU - Feighery, C.

AU - Kelleher, D.

AU - McManus, R.

PY - 2004/8

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N2 - In addition to the well-established association of coeliac disease (CD) with HLA-DQ (6p21) and possibly CTLA4 (2q33), there is considerable evidence for a susceptibility locus on chromosome 5q, which contains many potential candidates for inflammatory disease, including a cluster of cytokine genes in 5q31. CD cases and controls were genotyped for four single- nucleotide polymorphism (SNP) markers that together characterize >90% of the haplotype variation at the IBD5 locus encoding, among others, the SLC22A4 gene. IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. Haplotype frequencies do not differ significantly between CD cases and controls in the Irish population, and therefore the chromosome 5 CD susceptibility locus most likely lies elsewhere on 5q.

AB - In addition to the well-established association of coeliac disease (CD) with HLA-DQ (6p21) and possibly CTLA4 (2q33), there is considerable evidence for a susceptibility locus on chromosome 5q, which contains many potential candidates for inflammatory disease, including a cluster of cytokine genes in 5q31. CD cases and controls were genotyped for four single- nucleotide polymorphism (SNP) markers that together characterize >90% of the haplotype variation at the IBD5 locus encoding, among others, the SLC22A4 gene. IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. Haplotype frequencies do not differ significantly between CD cases and controls in the Irish population, and therefore the chromosome 5 CD susceptibility locus most likely lies elsewhere on 5q.

KW - 5q31

KW - Autoimmunity

KW - Coeliac disease

KW - Gluten sensitivity

KW - IBD5

KW - SLC22A4

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SN - 0001-2815

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JO - Tissue Antigens

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ER -

Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population

Abstract

Keywords

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