Gremlins: Is this what renal fibrogenesis has come to?

Madeline Murphy; Ruth McMahon; David W.P. Lappin; Hugh R. Brady

doi:10.1159/000063698

Gremlins: Is this what renal fibrogenesis has come to?

Madeline Murphy
, Ruth McMahon
, David W.P. Lappin
, Hugh R. Brady

Mater Misericordiae University Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Short survey › peer-review

20 Citations (Scopus)

Abstract

Gremlin is a member of the differential screening-selected gene aberrative in the neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists. Gremlin influences diverse processes in growth, differentiation and development. Increased expression of gremlin has recently been demonstrated in several models of diabetic nephropathy. Gremlin arrests the cell cycle in mesangial cells and has also been shown to be upregulated in transdifferentiated renal proximal tubular cells. This review summarizes emerging evidence implicating gremlin in the pathophysiology of glomerulosclerosis and tubulointerstitial fibrosis. Gremlin is a potential novel therapeutic target in progressive renal diseases.

Original language	English
Pages (from-to)	241-244
Number of pages	4
Journal	Experimental Nephrology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1159/000063698
Publication status	Published - 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bone morphogenetic proteins
drm
Extracellular matrix
Fibrogenesis
Gremlin
Hypertrophy
Kidney development
Mesangial cells
Transdifferentiation
Transforming growth factor-β
Tubule epithelial cells

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10.1159/000063698

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title = "Gremlins: Is this what renal fibrogenesis has come to?",

abstract = "Gremlin is a member of the differential screening-selected gene aberrative in the neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists. Gremlin influences diverse processes in growth, differentiation and development. Increased expression of gremlin has recently been demonstrated in several models of diabetic nephropathy. Gremlin arrests the cell cycle in mesangial cells and has also been shown to be upregulated in transdifferentiated renal proximal tubular cells. This review summarizes emerging evidence implicating gremlin in the pathophysiology of glomerulosclerosis and tubulointerstitial fibrosis. Gremlin is a potential novel therapeutic target in progressive renal diseases.",

keywords = "Bone morphogenetic proteins, drm, Extracellular matrix, Fibrogenesis, Gremlin, Hypertrophy, Kidney development, Mesangial cells, Transdifferentiation, Transforming growth factor-β, Tubule epithelial cells",

author = "Madeline Murphy and Ruth McMahon and Lappin, \{David W.P.\} and Brady, \{Hugh R.\}",

year = "2002",

doi = "10.1159/000063698",

language = "English",

volume = "10",

pages = "241--244",

journal = "Experimental Nephrology",

issn = "1018-7782",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Gremlins

T2 - Is this what renal fibrogenesis has come to?

AU - Murphy, Madeline

AU - McMahon, Ruth

AU - Lappin, David W.P.

AU - Brady, Hugh R.

PY - 2002

Y1 - 2002

N2 - Gremlin is a member of the differential screening-selected gene aberrative in the neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists. Gremlin influences diverse processes in growth, differentiation and development. Increased expression of gremlin has recently been demonstrated in several models of diabetic nephropathy. Gremlin arrests the cell cycle in mesangial cells and has also been shown to be upregulated in transdifferentiated renal proximal tubular cells. This review summarizes emerging evidence implicating gremlin in the pathophysiology of glomerulosclerosis and tubulointerstitial fibrosis. Gremlin is a potential novel therapeutic target in progressive renal diseases.

AB - Gremlin is a member of the differential screening-selected gene aberrative in the neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists. Gremlin influences diverse processes in growth, differentiation and development. Increased expression of gremlin has recently been demonstrated in several models of diabetic nephropathy. Gremlin arrests the cell cycle in mesangial cells and has also been shown to be upregulated in transdifferentiated renal proximal tubular cells. This review summarizes emerging evidence implicating gremlin in the pathophysiology of glomerulosclerosis and tubulointerstitial fibrosis. Gremlin is a potential novel therapeutic target in progressive renal diseases.

KW - Bone morphogenetic proteins

KW - drm

KW - Extracellular matrix

KW - Fibrogenesis

KW - Gremlin

KW - Hypertrophy

KW - Kidney development

KW - Mesangial cells

KW - Transdifferentiation

KW - Transforming growth factor-β

KW - Tubule epithelial cells

UR - https://www.scopus.com/pages/publications/0035991118

U2 - 10.1159/000063698

DO - 10.1159/000063698

M3 - Short survey

C2 - 12097827

AN - SCOPUS:0035991118

SN - 1018-7782

VL - 10

SP - 241

EP - 244

JO - Experimental Nephrology

JF - Experimental Nephrology

IS - 4

ER -

Gremlins: Is this what renal fibrogenesis has come to?

Abstract

UN SDGs

Keywords

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