Glycosylation and Integrin Regulation in Cancer

Integrins are transmembrane receptors that coordinate extracellular matrix (ECM)–cell and cell–cell interactions, signal transmission, gene expression, and cell function. The aberration of integrin function is one of the well-recognized mechanisms of cancer. The activity of integrins is strongly influenced by glycans through glycosylation events and the establishment of glycan-mediated interactions. Glycans represent a class of ubiquitous biomolecules that display an extraordinary complexity and diversity in both structure and function. Widely expressed both in the ECM and on the cell surface, they play a crucial role in mediating cell proliferation, survival, and metastasis during cancer. The purpose of this review is to provide an overview of how both glycosylation of integrins and integrin interaction with the cancer glyco-microenvironment can regulate cancer progression.