Genomic perspective on the bacillus causing paratyphoid B fever

Jane Hawkey; Lise Frézal; Alicia Tran Dien; Anna Zhukova; Derek Brown; Marie Anne Chattaway; Sandra Simon; Hidemasa Izumiya; Patricia I. Fields; Niall De Lappe; Lidia Kaftyreva; Xuebin Xu; Junko Isobe; Dominique Clermont; Elisabeth Njamkepo; Yukihiro Akeda; Sylvie Issenhuth-Jeanjean; Mariia Makarova; Yanan Wang; Martin Hunt; Brent M. Jenkins; Magali Ravel; Véronique Guibert; Estelle Serre; Zoya Matveeva; Laëtitia Fabre; Martin Cormican; Min Yue; Baoli Zhu; Masatomo Morita; Zamin Iqbal; Carolina Silva Nodari; Maria Pardos de la Gandara; François Xavier Weill

doi:10.1038/s41467-024-54418-4

Genomic perspective on the bacillus causing paratyphoid B fever

Jane Hawkey
, Lise Frézal
, Alicia Tran Dien
, Anna Zhukova
, Derek Brown
, Marie Anne Chattaway
, Sandra Simon
, Hidemasa Izumiya
, Patricia I. Fields
, Niall De Lappe
, Lidia Kaftyreva
, Xuebin Xu
, Junko Isobe
, Dominique Clermont
, Elisabeth Njamkepo
, Yukihiro Akeda
, Sylvie Issenhuth-Jeanjean
, Mariia Makarova
, Yanan Wang
, Martin Hunt

Brent M. Jenkins, Magali Ravel, Véronique Guibert, Estelle Serre, Zoya Matveeva, Laëtitia Fabre, Martin Cormican, Min Yue, Baoli Zhu, Masatomo Morita, Zamin Iqbal, Carolina Silva Nodari, Maria Pardos de la Gandara, François Xavier Weill

Bacteriology

Monash University
Université Paris Descartes-Sorbonne Paris Cité
Gustave Roussy
Scottish Microbiology Reference Laboratories
Colindale
Robert Koch Institute
National Institute of Infectious Diseases
Centers for Disease Control and Prevention
Galway University Hospital
Pasteur Institute of St Petersburg
Shanghai Municipal Centre for Disease Control and Prevention
Toyama Institute of Health
Henan Agricultural University
Institute of Microbiology Chinese Academy of Sciences
European Bioinformatics Institute
University of Oxford
NIHR Oxford Biomedical Research Centre
University of Oxford
Zhejiang University
University of Chinese Academy of Sciences
Milner Centre for Evolution

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

3 Citations (Scopus)

Abstract

Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.

Original language	English
Article number	10143
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-54418-4
Publication status	Published - Dec 2024

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10.1038/s41467-024-54418-4

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Hawkey, J., Frézal, L., Tran Dien, A., Zhukova, A., Brown, D., Chattaway, M. A., Simon, S., Izumiya, H., Fields, P. I., De Lappe, N., Kaftyreva, L., Xu, X., Isobe, J., Clermont, D., Njamkepo, E., Akeda, Y., Issenhuth-Jeanjean, S., Makarova, M., Wang, Y., ... Weill, F. X. (2024). Genomic perspective on the bacillus causing paratyphoid B fever. Nature Communications, 15(1), Article 10143. https://doi.org/10.1038/s41467-024-54418-4

@article{ffe78e6668ca441eb8c9809e71efa132,

title = "Genomic perspective on the bacillus causing paratyphoid B fever",

abstract = "Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.",

author = "Jane Hawkey and Lise Fr{\'e}zal and \{Tran Dien\}, Alicia and Anna Zhukova and Derek Brown and Chattaway, \{Marie Anne\} and Sandra Simon and Hidemasa Izumiya and Fields, \{Patricia I.\} and \{De Lappe\}, Niall and Lidia Kaftyreva and Xuebin Xu and Junko Isobe and Dominique Clermont and Elisabeth Njamkepo and Yukihiro Akeda and Sylvie Issenhuth-Jeanjean and Mariia Makarova and Yanan Wang and Martin Hunt and Jenkins, \{Brent M.\} and Magali Ravel and V{\'e}ronique Guibert and Estelle Serre and Zoya Matveeva and La{\"e}titia Fabre and Martin Cormican and Min Yue and Baoli Zhu and Masatomo Morita and Zamin Iqbal and \{Silva Nodari\}, Carolina and \{Pardos de la Gandara\}, Maria and Weill, \{Fran{\c c}ois Xavier\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41467-024-54418-4",

language = "English",

volume = "15",

journal = "Nature Communications",

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Hawkey, J, Frézal, L, Tran Dien, A, Zhukova, A, Brown, D, Chattaway, MA, Simon, S, Izumiya, H, Fields, PI, De Lappe, N, Kaftyreva, L, Xu, X, Isobe, J, Clermont, D, Njamkepo, E, Akeda, Y, Issenhuth-Jeanjean, S, Makarova, M, Wang, Y, Hunt, M, Jenkins, BM, Ravel, M, Guibert, V, Serre, E, Matveeva, Z, Fabre, L, Cormican, M, Yue, M, Zhu, B, Morita, M, Iqbal, Z, Silva Nodari, C, Pardos de la Gandara, M & Weill, FX 2024, 'Genomic perspective on the bacillus causing paratyphoid B fever', Nature Communications, vol. 15, no. 1, 10143. https://doi.org/10.1038/s41467-024-54418-4

TY - JOUR

T1 - Genomic perspective on the bacillus causing paratyphoid B fever

AU - Hawkey, Jane

AU - Frézal, Lise

AU - Tran Dien, Alicia

AU - Zhukova, Anna

AU - Brown, Derek

AU - Chattaway, Marie Anne

AU - Simon, Sandra

AU - Izumiya, Hidemasa

AU - Fields, Patricia I.

AU - De Lappe, Niall

AU - Kaftyreva, Lidia

AU - Xu, Xuebin

AU - Isobe, Junko

AU - Clermont, Dominique

AU - Njamkepo, Elisabeth

AU - Akeda, Yukihiro

AU - Issenhuth-Jeanjean, Sylvie

AU - Makarova, Mariia

AU - Wang, Yanan

AU - Hunt, Martin

AU - Jenkins, Brent M.

AU - Ravel, Magali

AU - Guibert, Véronique

AU - Serre, Estelle

AU - Matveeva, Zoya

AU - Fabre, Laëtitia

AU - Cormican, Martin

AU - Yue, Min

AU - Zhu, Baoli

AU - Morita, Masatomo

AU - Iqbal, Zamin

AU - Silva Nodari, Carolina

AU - Pardos de la Gandara, Maria

AU - Weill, François Xavier

PY - 2024/12

Y1 - 2024/12

N2 - Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.

AB - Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.

UR - https://www.scopus.com/pages/publications/85211440599

U2 - 10.1038/s41467-024-54418-4

DO - 10.1038/s41467-024-54418-4

M3 - Article

C2 - 39658567

AN - SCOPUS:85211440599

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 10143

ER -

Genomic perspective on the bacillus causing paratyphoid B fever

Abstract

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