Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

The COVID-19 Genomics UK (COG-UK) Consortium

doi:10.1038/s41467-022-28371-z

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

The COVID-19 Genomics UK (COG-UK) Consortium

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

10 Citations (Scopus)

Abstract

Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

Original language	English
Article number	1012
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-28371-z
Publication status	Published - 1 Dec 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41467-022-28371-z

Cite this

@article{77e21513cdff460e873ff9f890423abf,

title = "Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission",

abstract = "Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.",

author = "\{The COVID-19 Genomics UK (COG-UK) Consortium\} and Dinesh Aggarwal and Page, \{Andrew J.\} and Ulf Schaefer and Savva, \{George M.\} and Richard Myers and Erik Volz and Nicholas Ellaby and Steven Platt and Natalie Groves and Eileen Gallagher and Tumelty, \{Niamh M.\} and \{Le Viet\}, Thanh and Hughes, \{Gareth J.\} and Cong Chen and Charlie Turner and Sophie Logan and Abbie Harrison and Cherian Koshy and Amy Ash and Emma Wise and Nathan Moore and Matilde Mori and Nick Cortes and Jessica Lynch and Stephen Kidd and Fairley, \{Derek J.\} and Tanya Curran and McKenna, \{James P.\} and Helen Adams and Christophe Fraser and Tanya Golubchik and David Bonsall and Hassan-Ibrahim, \{Mohammed O.\} and Malone, \{Cassandra S.\} and Cogger, \{Benjamin J.\} and Michelle Wantoch and Nicola Reynolds and Ben Warne and Joshua Maksimovic and Karla Spellman and Kathryn McCluggage and Michaela John and Robert Beer and Safiah Afifi and Sian Morgan and Angela Marchbank and Anna Price and Christine Kitchen and Huw Gulliver and Ian Merrick and Joel Southgate and Martyn Guest and Robert Munn and Trudy Workman and Connor, \{Thomas R.\} and William Fuller and Catherine Bresner and Snell, \{Luke B.\} and Amita Patel and Themoula Charalampous and Gaia Nebbia and Rahul Batra and Jonathan Edgeworth and Robson, \{Samuel C.\} and Beckett, \{Angela H.\} and Aanensen, \{David M.\} and Underwood, \{Anthony P.\} and Yeats, \{Corin A.\} and Khalil Abudahab and Taylor, \{Ben E.W.\} and Mirko Menegazzo and Gemma Clark and Wendy Smith and Manjinder Khakh and Fleming, \{Vicki M.\} and Lister, \{Michelle M.\} and Howson-Wells, \{Hannah C.\} and Louise Berry and Tim Boswell and Amelia Joseph and Iona Willingham and Carl Jones and Christopher Holmes and Paul Bird and Thomas Helmer and Karlie Fallon and Julian Tang and Veena Raviprakash and Sharon Campbell and Nicola Sheriff and Victoria Blakey and Williams, \{Lesley Anne\} and Loose, \{Matthew W.\} and Nadine Holmes and Christopher Moore and Matthew Carlile and Victoria Wright and Fei Sang and Johnny Debebe and Dorman, \{Matthew J.\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

day = "1",

doi = "10.1038/s41467-022-28371-z",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

AU - The COVID-19 Genomics UK (COG-UK) Consortium

AU - Aggarwal, Dinesh

AU - Page, Andrew J.

AU - Schaefer, Ulf

AU - Savva, George M.

AU - Myers, Richard

AU - Volz, Erik

AU - Ellaby, Nicholas

AU - Platt, Steven

AU - Groves, Natalie

AU - Gallagher, Eileen

AU - Tumelty, Niamh M.

AU - Le Viet, Thanh

AU - Hughes, Gareth J.

AU - Chen, Cong

AU - Turner, Charlie

AU - Logan, Sophie

AU - Harrison, Abbie

AU - Koshy, Cherian

AU - Ash, Amy

AU - Wise, Emma

AU - Moore, Nathan

AU - Mori, Matilde

AU - Cortes, Nick

AU - Lynch, Jessica

AU - Kidd, Stephen

AU - Fairley, Derek J.

AU - Curran, Tanya

AU - McKenna, James P.

AU - Adams, Helen

AU - Fraser, Christophe

AU - Golubchik, Tanya

AU - Bonsall, David

AU - Hassan-Ibrahim, Mohammed O.

AU - Malone, Cassandra S.

AU - Cogger, Benjamin J.

AU - Wantoch, Michelle

AU - Reynolds, Nicola

AU - Warne, Ben

AU - Maksimovic, Joshua

AU - Spellman, Karla

AU - McCluggage, Kathryn

AU - John, Michaela

AU - Beer, Robert

AU - Afifi, Safiah

AU - Morgan, Sian

AU - Marchbank, Angela

AU - Price, Anna

AU - Kitchen, Christine

AU - Gulliver, Huw

AU - Merrick, Ian

AU - Southgate, Joel

AU - Guest, Martyn

AU - Munn, Robert

AU - Workman, Trudy

AU - Connor, Thomas R.

AU - Fuller, William

AU - Bresner, Catherine

AU - Snell, Luke B.

AU - Patel, Amita

AU - Charalampous, Themoula

AU - Nebbia, Gaia

AU - Batra, Rahul

AU - Edgeworth, Jonathan

AU - Robson, Samuel C.

AU - Beckett, Angela H.

AU - Aanensen, David M.

AU - Underwood, Anthony P.

AU - Yeats, Corin A.

AU - Abudahab, Khalil

AU - Taylor, Ben E.W.

AU - Menegazzo, Mirko

AU - Clark, Gemma

AU - Smith, Wendy

AU - Khakh, Manjinder

AU - Fleming, Vicki M.

AU - Lister, Michelle M.

AU - Howson-Wells, Hannah C.

AU - Berry, Louise

AU - Boswell, Tim

AU - Joseph, Amelia

AU - Willingham, Iona

AU - Jones, Carl

AU - Holmes, Christopher

AU - Bird, Paul

AU - Helmer, Thomas

AU - Fallon, Karlie

AU - Tang, Julian

AU - Raviprakash, Veena

AU - Campbell, Sharon

AU - Sheriff, Nicola

AU - Blakey, Victoria

AU - Williams, Lesley Anne

AU - Loose, Matthew W.

AU - Holmes, Nadine

AU - Moore, Christopher

AU - Carlile, Matthew

AU - Wright, Victoria

AU - Sang, Fei

AU - Debebe, Johnny

AU - Dorman, Matthew J.

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

AB - Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

UR - https://www.scopus.com/pages/publications/85125215535

U2 - 10.1038/s41467-022-28371-z

DO - 10.1038/s41467-022-28371-z

M3 - Article

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1012

ER -

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Abstract

UN SDGs

Access to Document

Other files and links

Cite this