Genome-wide association analysis identifies three new breast cancer susceptibility loci

Maya Ghoussaini; Olivia Fletcher; Kyriaki Michailidou; Clare Turnbull; Marjanka K. Schmidt; Ed Dicks; Joe Dennis; Qin Wang; Manjeet K Humphreys; Craig Luccarini; Caroline Baynes; Don Conroy; Melanie Maranian; Shahana Ahmed; Kristy Driver; Nichola Johnson; Nicholas Orr; Isabel Dos Santos Silva; Quinten Waisfisz; Hanne Meijers-Heijboer; Andre G Uitterlinden; Fernando Rivadeneira; Per Hall; Kamila Czene; Astrid Irwanto; Jianjun Liu; Heli Nevanlinna; Kristiina Aittomäki; Carl Blomqvist; Alfons Meindl; Rita K Schmutzler; Bertram Müller-Myhsok; Peter Lichtner; Jenny Chang-Claude; Rebecca Hein; Stefan Nickels; Dieter Flesch-Janys; Helen Tsimiklis; Enes Makalic; Daniel Schmidt; Minh Bui; John L Hopper; Carmel Apicella; Daniel J Park; Melissa Southey; David J Hunter; Stephen J Chanock; Annegien Broeks; Senno Verhoef; Frans B L Hogervorst; Peter A Fasching; Michael P Lux; Matthias W Beckmann; Arif B Ekici; Elinor Sawyer; Ian Tomlinson; Michael Kerin; Frederik Marme; Andreas Schneeweiss; Christof Sohn; Barbara Burwinkel; Pascal Guénel; Thér̈se Truong; Emilie Cordina-Duverger; Florence Menegaux; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Roger L. Milne; M Rosario Alonso; Anna González-Neira; Javier Benítez; Hoda Anton-Culver; Argyrios Ziogas; Leslie Bernstein; Christina Clarke Dur; Hermann Brenner; Heiko Müller; Volker Arndt; Christa Stegmaier; Christina Justenhoven; Hiltrud Brauch; Thomas Brüning; Shan Wang-Gohrke; Ursula Eilber; Thilo Dörk; Peter Schürmann; Michael Bremer; Peter Hillemanns; Natalia V Bogdanova; Natalia N Antonenkova; Yuri I Rogov; Johann H Karstens; Marina Bermisheva; Darya Prokofieva; Elza Khusnutdinova; Annika Lindblom; Sara Margolin; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Diether Lambrechts; Betul T Yesilyurt; Giuseppe Floris; Karin Leunen; Siranoush Manoukian; Bernardo Bonanni; Stefano Fortuzzi; Paolo Peterlongo; Fergus J Couch; Xianshu Wang; Kristen Stevens; Adam Lee; Graham G Giles; Laura Baglietto; Gianluca Severi; Catriona McLean; Grethe Grenaker Alnæs; Vessela Kristensen; Anne-Lise Børrensen-Dale; Esther M John; Alexander Miron; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Saila Kauppila; Irene L Andrulis; Gord Glendon; Anna Marie Mulligan; Peter Devilee; Christie J Van Asperen; Robert A. E. M. Tollenaar; Caroline Seynaeve; Jonine D Figueroa; Montserrat Garcia-Closas; Louise Brinton; Jolanta Lissowska; Maartje J Hooning; Antoinette Hollestelle; Rogier A Oldenburg; Ans M W Van Den Ouweland; Angela Cox; Malcolm W R Reed; Mitul Shah; Ania Jakubowska; Lubinski Jan; Katarzyna Jaworska; Katarzyna Durda; Michael Jones; Minouk Schoemaker; Alan Ashworth; Anthony Swerdlow; Jonathan Beesley; Xiaoqing Chen; Kenneth R Muir; Artitaya Lophatananon; Suthee Rattanamongkongul; Arkom Chaiwerawattana; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Chen-Yang Shen; Jyh-Cherng Yu; Pei-Ei Wu; Chia-Ni Hsiung; Annie Perkins; Ruth Swann; Louiza Velentzis; Diana M Eccles; Will J Tapper; Susan M Gerty; Nikki J Graham; Bruce A J Ponder; Georgia Chenevix-Trench; Paul D P Pharoah; Mark Lathrop; Alison M. Dunning; Nazneen Rahman; Julian Peto; Douglas F Easton

doi:10.13025/28712

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Maya Ghoussaini
, Olivia Fletcher
, Kyriaki Michailidou
, Clare Turnbull
, Marjanka K. Schmidt
, Ed Dicks
, Joe Dennis
, Qin Wang
, Manjeet K Humphreys
, Craig Luccarini
, Caroline Baynes
, Don Conroy
, Melanie Maranian
, Shahana Ahmed
, Kristy Driver
, Nichola Johnson
, Nicholas Orr
, Isabel Dos Santos Silva
, Quinten Waisfisz
, Hanne Meijers-Heijboer

Andre G Uitterlinden, Fernando Rivadeneira, Per Hall, Kamila Czene, Astrid Irwanto, Jianjun Liu, Heli Nevanlinna, Kristiina Aittomäki, Carl Blomqvist, Alfons Meindl, Rita K Schmutzler, Bertram Müller-Myhsok, Peter Lichtner, Jenny Chang-Claude, Rebecca Hein, Stefan Nickels, Dieter Flesch-Janys, Helen Tsimiklis, Enes Makalic, Daniel Schmidt, Minh Bui, John L Hopper, Carmel Apicella, Daniel J Park, Melissa Southey, David J Hunter, Stephen J Chanock, Annegien Broeks, Senno Verhoef, Frans B L Hogervorst, Peter A Fasching, Michael P Lux, Matthias W Beckmann, Arif B Ekici, Elinor Sawyer, Ian Tomlinson, Michael Kerin, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Barbara Burwinkel, Pascal Guénel, Thér̈se Truong, Emilie Cordina-Duverger, Florence Menegaux, Stig E Bojesen, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Roger L. Milne, M Rosario Alonso, Anna González-Neira, Javier Benítez, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina Clarke Dur, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Christina Justenhoven, Hiltrud Brauch, Thomas Brüning, Shan Wang-Gohrke, Ursula Eilber, Thilo Dörk, Peter Schürmann, Michael Bremer, Peter Hillemanns, Natalia V Bogdanova, Natalia N Antonenkova, Yuri I Rogov, Johann H Karstens, Marina Bermisheva, Darya Prokofieva, Elza Khusnutdinova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Diether Lambrechts, Betul T Yesilyurt, Giuseppe Floris, Karin Leunen, Siranoush Manoukian, Bernardo Bonanni, Stefano Fortuzzi, Paolo Peterlongo, Fergus J Couch, Xianshu Wang, Kristen Stevens, Adam Lee, Graham G Giles, Laura Baglietto, Gianluca Severi, Catriona McLean, Grethe Grenaker Alnæs, Vessela Kristensen, Anne-Lise Børrensen-Dale, Esther M John, Alexander Miron, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Saila Kauppila, Irene L Andrulis, Gord Glendon, Anna Marie Mulligan, Peter Devilee, Christie J Van Asperen, Robert A. E. M. Tollenaar, Caroline Seynaeve, Jonine D Figueroa, Montserrat Garcia-Closas, Louise Brinton, Jolanta Lissowska, Maartje J Hooning, Antoinette Hollestelle, Rogier A Oldenburg, Ans M W Van Den Ouweland, Angela Cox, Malcolm W R Reed, Mitul Shah, Ania Jakubowska, Lubinski Jan, Katarzyna Jaworska, Katarzyna Durda, Michael Jones, Minouk Schoemaker, Alan Ashworth, Anthony Swerdlow, Jonathan Beesley, Xiaoqing Chen, Kenneth R Muir, Artitaya Lophatananon, Suthee Rattanamongkongul, Arkom Chaiwerawattana, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Chen-Yang Shen, Jyh-Cherng Yu, Pei-Ei Wu, Chia-Ni Hsiung, Annie Perkins, Ruth Swann, Louiza Velentzis, Diana M Eccles, Will J Tapper, Susan M Gerty, Nikki J Graham, Bruce A J Ponder, Georgia Chenevix-Trench, Paul D P Pharoah, Mark Lathrop, Alison M. Dunning, Nazneen Rahman, Julian Peto, Douglas F Easton

Surgery

University of Cambridge
Divisions of Molecular Pathology and Cancer Therapeutics
Antoni Van Leeuwenhoek Hospital
London School of Hygiene and Tropical Medicine
VU University Medical Center
Erasmus MC
Karolinska Institutet
Helsinki University Central Hospital
A*STAR
Technical University Munich
University of Cologne
Max Planck Institute of Psychiatry
German Research Center for Environmental Health
German Cancer Research Center
Division of Cancer Epidemiology
Guys and St Thomas' NHS Foundation Trust
University Medical Center Hamburg-Eppendorf
University of Melbourne
Melbourne School of Population and Global Health
Harvard School of Public Health
National Cancer Institute (NCI)
The Netherlands Cancer Institute
University Hospital Erlangen
University of Erlangen-Nuremberg
King's College London
Wellcome Trust Centre for Human Genetics
Galway University Hospital
Heidelberg University
Inserm
Université Paris-Sud
Gentofte University Hospital
Cell Division and Cancer Group
University of California, Irvine
City of Hope National Med Center
Cancer Prevention Institute of California
Saarland Cancer Registry
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
University of Tübingen
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
Johanniter Krankenhaus
Ulm University
Hannover Medical School
N.N. Alexandrov Research Institute of Oncology and Medical Radiology
Russian Academy of Sciences
Institute of Clinical Medicine
Kuopio University Hospital
University of Eastern Finland
VIB Center for the Biology of Disease
KU Leuven– University Hospital Leuven
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Department of Experimental Oncology
IFOM - The FIRC Institute of Molecular Oncology
Fondazione IRCCS (Istituto di Ricovero e Cura A Carattere Scientifico)
Mayo Clinic
Cancer Council Victoria
Alfred Hospital
Faculty of Medicine
University of Oslo
Stanford University School of Medicine
Dana-Farber Cancer Institute
University of Oulu
Mt Sinai Hospital
University of Toronto Faculty of Medicine
Mount Sinai Hospital, Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute
Keenan Research Centre for Biomedical Science
Leiden University Medical Center
M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Josephine Nefkens Institute - JNI
University of Sheffield
Pomeranian Medical University in Szczecin
QIMR Berghofer Medical Research Institute
Warwick Medical School
Srinakharainwirot University
Ministry of Public Health
Seoul National University College of Medicine
Academia Sinica, Institute of Biomedical Sciences
Tri-Service General Hospital
University of Westminster
University of Southampton, Faculty of Medicine
Cancer Research UK Cambridge Institute
Commissariat À l'Energie Atomique
CEPH-Fondation Jean Dausset

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

248 Citations (Scopus)

Abstract

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for g1/48% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in g1/470,000 cases and ĝ̂1/468,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 - 10 g³⁵), 12q24 (rs1292011; P = 4.3 - 10 g¹⁹) and 21q21 (rs2823093; P = 1.1 - 10 g¹²). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.

Original language	English
Pages (from-to)	312-318
Number of pages	7
Journal	Nature Genetics
Volume	44
Issue number	3
DOIs	https://doi.org/10.13025/28712 https://doi.org/10.1038/ng.1049
Publication status	Published - 1 Mar 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.13025/28712Licence: CC BY-NC-ND
10.1038/ng.1049

Cite this

Ghoussaini, M., Fletcher, O., Michailidou, K., Turnbull, C., Schmidt, M. K., Dicks, E., Dennis, J., Wang, Q., Humphreys, M. K., Luccarini, C., Baynes, C., Conroy, D., Maranian, M., Ahmed, S., Driver, K., Johnson, N., Orr, N., Dos Santos Silva, I., Waisfisz, Q., ... Easton, D. F. (2012). Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature Genetics, 44(3), 312-318. https://doi.org/10.13025/28712, https://doi.org/10.1038/ng.1049

@article{83bc9476f2054eb9b9cb5f5c799c40ca,

title = "Genome-wide association analysis identifies three new breast cancer susceptibility loci",

abstract = "Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for g1/48\% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in g1/470,000 cases and {\^ĝ}1/468,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 - 10 g35), 12q24 (rs1292011; P = 4.3 - 10 g19) and 21q21 (rs2823093; P = 1.1 - 10 g12). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.",

author = "Maya Ghoussaini and Olivia Fletcher and Kyriaki Michailidou and Clare Turnbull and Schmidt, \{Marjanka K.\} and Ed Dicks and Joe Dennis and Qin Wang and Humphreys, \{Manjeet K\} and Craig Luccarini and Caroline Baynes and Don Conroy and Melanie Maranian and Shahana Ahmed and Kristy Driver and Nichola Johnson and Nicholas Orr and \{Dos Santos Silva\}, Isabel and Quinten Waisfisz and Hanne Meijers-Heijboer and Uitterlinden, \{Andre G\} and Fernando Rivadeneira and Per Hall and Kamila Czene and Astrid Irwanto and Jianjun Liu and Heli Nevanlinna and Kristiina Aittom{\"a}ki and Carl Blomqvist and Alfons Meindl and Schmutzler, \{Rita K\} and Bertram M{\"u}ller-Myhsok and Peter Lichtner and Jenny Chang-Claude and Rebecca Hein and Stefan Nickels and Dieter Flesch-Janys and Helen Tsimiklis and Enes Makalic and Daniel Schmidt and Minh Bui and Hopper, \{John L\} and Carmel Apicella and Park, \{Daniel J\} and Melissa Southey and Hunter, \{David J\} and Chanock, \{Stephen J\} and Annegien Broeks and Senno Verhoef and Hogervorst, \{Frans B L\} and Fasching, \{Peter A\} and Lux, \{Michael P\} and Beckmann, \{Matthias W\} and Ekici, \{Arif B\} and Elinor Sawyer and Ian Tomlinson and Michael Kerin and Frederik Marme and Andreas Schneeweiss and Christof Sohn and Barbara Burwinkel and Pascal Gu{\'e}nel and Th{\'e}{\"r}se Truong and Emilie Cordina-Duverger and Florence Menegaux and Bojesen, \{Stig E\} and Nordestgaard, \{B{\o}rge G\} and Nielsen, \{Sune F\} and Henrik Flyger and Milne, \{Roger L.\} and Alonso, \{M Rosario\} and Anna Gonz{\'a}lez-Neira and Javier Ben{\'i}tez and Hoda Anton-Culver and Argyrios Ziogas and Leslie Bernstein and Dur, \{Christina Clarke\} and Hermann Brenner and Heiko M{\"u}ller and Volker Arndt and Christa Stegmaier and Christina Justenhoven and Hiltrud Brauch and Thomas Br{\"u}ning and Shan Wang-Gohrke and Ursula Eilber and Thilo D{\"o}rk and Peter Sch{\"u}rmann and Michael Bremer and Peter Hillemanns and Bogdanova, \{Natalia V\} and Antonenkova, \{Natalia N\} and Rogov, \{Yuri I\} and Karstens, \{Johann H\} and Marina Bermisheva and Darya Prokofieva and Elza Khusnutdinova and Annika Lindblom and Sara Margolin and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Hartikainen, \{Jaana M\} and Diether Lambrechts and Yesilyurt, \{Betul T\} and Giuseppe Floris and Karin Leunen and Siranoush Manoukian and Bernardo Bonanni and Stefano Fortuzzi and Paolo Peterlongo and Couch, \{Fergus J\} and Xianshu Wang and Kristen Stevens and Adam Lee and Giles, \{Graham G\} and Laura Baglietto and Gianluca Severi and Catriona McLean and Aln{\ae}s, \{Grethe Grenaker\} and Vessela Kristensen and Anne-Lise B{\o}rrensen-Dale and John, \{Esther M\} and Alexander Miron and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Saila Kauppila and Andrulis, \{Irene L\} and Gord Glendon and Mulligan, \{Anna Marie\} and Peter Devilee and \{Van Asperen\}, \{Christie J\} and Tollenaar, \{Robert A. E. M.\} and Caroline Seynaeve and Figueroa, \{Jonine D\} and Montserrat Garcia-Closas and Louise Brinton and Jolanta Lissowska and Hooning, \{Maartje J\} and Antoinette Hollestelle and Oldenburg, \{Rogier A\} and \{Van Den Ouweland\}, \{Ans M W\} and Angela Cox and Reed, \{Malcolm W R\} and Mitul Shah and Ania Jakubowska and Lubinski Jan and Katarzyna Jaworska and Katarzyna Durda and Michael Jones and Minouk Schoemaker and Alan Ashworth and Anthony Swerdlow and Jonathan Beesley and Xiaoqing Chen and Muir, \{Kenneth R\} and Artitaya Lophatananon and Suthee Rattanamongkongul and Arkom Chaiwerawattana and Daehee Kang and Keun-Young Yoo and Dong-Young Noh and Chen-Yang Shen and Jyh-Cherng Yu and Pei-Ei Wu and Chia-Ni Hsiung and Annie Perkins and Ruth Swann and Louiza Velentzis and Eccles, \{Diana M\} and Tapper, \{Will J\} and Gerty, \{Susan M\} and Graham, \{Nikki J\} and Ponder, \{Bruce A J\} and Georgia Chenevix-Trench and Pharoah, \{Paul D P\} and Mark Lathrop and Dunning, \{Alison M.\} and Nazneen Rahman and Julian Peto and Easton, \{Douglas F\}",

year = "2012",

month = mar,

day = "1",

doi = "10.13025/28712",

language = "English",

volume = "44",

pages = "312--318",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "3",

}

Ghoussaini, M, Fletcher, O, Michailidou, K, Turnbull, C, Schmidt, MK, Dicks, E, Dennis, J, Wang, Q, Humphreys, MK, Luccarini, C, Baynes, C, Conroy, D, Maranian, M, Ahmed, S, Driver, K, Johnson, N, Orr, N, Dos Santos Silva, I, Waisfisz, Q, Meijers-Heijboer, H, Uitterlinden, AG, Rivadeneira, F, Hall, P, Czene, K, Irwanto, A, Liu, J, Nevanlinna, H, Aittomäki, K, Blomqvist, C, Meindl, A, Schmutzler, RK, Müller-Myhsok, B, Lichtner, P, Chang-Claude, J, Hein, R, Nickels, S, Flesch-Janys, D, Tsimiklis, H, Makalic, E, Schmidt, D, Bui, M, Hopper, JL, Apicella, C, Park, DJ, Southey, M, Hunter, DJ, Chanock, SJ, Broeks, A, Verhoef, S, Hogervorst, FBL, Fasching, PA, Lux, MP, Beckmann, MW, Ekici, AB, Sawyer, E, Tomlinson, I, Kerin, M, Marme, F, Schneeweiss, A, Sohn, C, Burwinkel, B, Guénel, P, Truong, T, Cordina-Duverger, E, Menegaux, F, Bojesen, SE, Nordestgaard, BG, Nielsen, SF, Flyger, H, Milne, RL, Alonso, MR, González-Neira, A, Benítez, J, Anton-Culver, H, Ziogas, A, Bernstein, L, Dur, CC, Brenner, H, Müller, H, Arndt, V, Stegmaier, C, Justenhoven, C, Brauch, H, Brüning, T, Wang-Gohrke, S, Eilber, U, Dörk, T, Schürmann, P, Bremer, M, Hillemanns, P, Bogdanova, NV, Antonenkova, NN, Rogov, YI, Karstens, JH, Bermisheva, M, Prokofieva, D, Khusnutdinova, E, Lindblom, A, Margolin, S, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Lambrechts, D, Yesilyurt, BT, Floris, G, Leunen, K, Manoukian, S, Bonanni, B, Fortuzzi, S, Peterlongo, P, Couch, FJ, Wang, X, Stevens, K, Lee, A, Giles, GG, Baglietto, L, Severi, G, McLean, C, Alnæs, GG, Kristensen, V, Børrensen-Dale, A-L, John, EM, Miron, A, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Kauppila, S, Andrulis, IL, Glendon, G, Mulligan, AM, Devilee, P, Van Asperen, CJ, Tollenaar, RAEM, Seynaeve, C, Figueroa, JD, Garcia-Closas, M, Brinton, L, Lissowska, J, Hooning, MJ, Hollestelle, A, Oldenburg, RA, Van Den Ouweland, AMW, Cox, A, Reed, MWR, Shah, M, Jakubowska, A, Jan, L, Jaworska, K, Durda, K, Jones, M, Schoemaker, M, Ashworth, A, Swerdlow, A, Beesley, J, Chen, X, Muir, KR, Lophatananon, A, Rattanamongkongul, S, Chaiwerawattana, A, Kang, D, Yoo, K-Y, Noh, D-Y, Shen, C-Y, Yu, J-C, Wu, P-E, Hsiung, C-N, Perkins, A, Swann, R, Velentzis, L, Eccles, DM, Tapper, WJ, Gerty, SM, Graham, NJ, Ponder, BAJ, Chenevix-Trench, G, Pharoah, PDP, Lathrop, M, Dunning, AM, Rahman, N, Peto, J & Easton, DF 2012, 'Genome-wide association analysis identifies three new breast cancer susceptibility loci', Nature Genetics, vol. 44, no. 3, pp. 312-318. https://doi.org/10.13025/28712, https://doi.org/10.1038/ng.1049

TY - JOUR

T1 - Genome-wide association analysis identifies three new breast cancer susceptibility loci

AU - Ghoussaini, Maya

AU - Fletcher, Olivia

AU - Michailidou, Kyriaki

AU - Turnbull, Clare

AU - Schmidt, Marjanka K.

AU - Dicks, Ed

AU - Dennis, Joe

AU - Wang, Qin

AU - Humphreys, Manjeet K

AU - Luccarini, Craig

AU - Baynes, Caroline

AU - Conroy, Don

AU - Maranian, Melanie

AU - Ahmed, Shahana

AU - Driver, Kristy

AU - Johnson, Nichola

AU - Orr, Nicholas

AU - Dos Santos Silva, Isabel

AU - Waisfisz, Quinten

AU - Meijers-Heijboer, Hanne

AU - Uitterlinden, Andre G

AU - Rivadeneira, Fernando

AU - Hall, Per

AU - Czene, Kamila

AU - Irwanto, Astrid

AU - Liu, Jianjun

AU - Nevanlinna, Heli

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Meindl, Alfons

AU - Schmutzler, Rita K

AU - Müller-Myhsok, Bertram

AU - Lichtner, Peter

AU - Chang-Claude, Jenny

AU - Hein, Rebecca

AU - Nickels, Stefan

AU - Flesch-Janys, Dieter

AU - Tsimiklis, Helen

AU - Makalic, Enes

AU - Schmidt, Daniel

AU - Bui, Minh

AU - Hopper, John L

AU - Apicella, Carmel

AU - Park, Daniel J

AU - Southey, Melissa

AU - Hunter, David J

AU - Chanock, Stephen J

AU - Broeks, Annegien

AU - Verhoef, Senno

AU - Hogervorst, Frans B L

AU - Fasching, Peter A

AU - Lux, Michael P

AU - Beckmann, Matthias W

AU - Ekici, Arif B

AU - Sawyer, Elinor

AU - Tomlinson, Ian

AU - Kerin, Michael

AU - Marme, Frederik

AU - Schneeweiss, Andreas

AU - Sohn, Christof

AU - Burwinkel, Barbara

AU - Guénel, Pascal

AU - Truong, Thér̈se

AU - Cordina-Duverger, Emilie

AU - Menegaux, Florence

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

AU - Nielsen, Sune F

AU - Flyger, Henrik

AU - Milne, Roger L.

AU - Alonso, M Rosario

AU - González-Neira, Anna

AU - Benítez, Javier

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Bernstein, Leslie

AU - Dur, Christina Clarke

AU - Brenner, Hermann

AU - Müller, Heiko

AU - Arndt, Volker

AU - Stegmaier, Christa

AU - Justenhoven, Christina

AU - Brauch, Hiltrud

AU - Brüning, Thomas

AU - Wang-Gohrke, Shan

AU - Eilber, Ursula

AU - Dörk, Thilo

AU - Schürmann, Peter

AU - Bremer, Michael

AU - Hillemanns, Peter

AU - Bogdanova, Natalia V

AU - Antonenkova, Natalia N

AU - Rogov, Yuri I

AU - Karstens, Johann H

AU - Bermisheva, Marina

AU - Prokofieva, Darya

AU - Khusnutdinova, Elza

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M

AU - Lambrechts, Diether

AU - Yesilyurt, Betul T

AU - Floris, Giuseppe

AU - Leunen, Karin

AU - Manoukian, Siranoush

AU - Bonanni, Bernardo

AU - Fortuzzi, Stefano

AU - Peterlongo, Paolo

AU - Couch, Fergus J

AU - Wang, Xianshu

AU - Stevens, Kristen

AU - Lee, Adam

AU - Giles, Graham G

AU - Baglietto, Laura

AU - Severi, Gianluca

AU - McLean, Catriona

AU - Alnæs, Grethe Grenaker

AU - Kristensen, Vessela

AU - Børrensen-Dale, Anne-Lise

AU - John, Esther M

AU - Miron, Alexander

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Kauppila, Saila

AU - Andrulis, Irene L

AU - Glendon, Gord

AU - Mulligan, Anna Marie

AU - Devilee, Peter

AU - Van Asperen, Christie J

AU - Tollenaar, Robert A. E. M.

AU - Seynaeve, Caroline

AU - Figueroa, Jonine D

AU - Garcia-Closas, Montserrat

AU - Brinton, Louise

AU - Lissowska, Jolanta

AU - Hooning, Maartje J

AU - Hollestelle, Antoinette

AU - Oldenburg, Rogier A

AU - Van Den Ouweland, Ans M W

AU - Cox, Angela

AU - Reed, Malcolm W R

AU - Shah, Mitul

AU - Jakubowska, Ania

AU - Jan, Lubinski

AU - Jaworska, Katarzyna

AU - Durda, Katarzyna

AU - Jones, Michael

AU - Schoemaker, Minouk

AU - Ashworth, Alan

AU - Swerdlow, Anthony

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - Muir, Kenneth R

AU - Lophatananon, Artitaya

AU - Rattanamongkongul, Suthee

AU - Chaiwerawattana, Arkom

AU - Kang, Daehee

AU - Yoo, Keun-Young

AU - Noh, Dong-Young

AU - Shen, Chen-Yang

AU - Yu, Jyh-Cherng

AU - Wu, Pei-Ei

AU - Hsiung, Chia-Ni

AU - Perkins, Annie

AU - Swann, Ruth

AU - Velentzis, Louiza

AU - Eccles, Diana M

AU - Tapper, Will J

AU - Gerty, Susan M

AU - Graham, Nikki J

AU - Ponder, Bruce A J

AU - Chenevix-Trench, Georgia

AU - Pharoah, Paul D P

AU - Lathrop, Mark

AU - Dunning, Alison M.

AU - Rahman, Nazneen

AU - Peto, Julian

AU - Easton, Douglas F

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for g1/48% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in g1/470,000 cases and ĝ̂1/468,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 - 10 g35), 12q24 (rs1292011; P = 4.3 - 10 g19) and 21q21 (rs2823093; P = 1.1 - 10 g12). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.

AB - Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for g1/48% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in g1/470,000 cases and ĝ̂1/468,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 - 10 g35), 12q24 (rs1292011; P = 4.3 - 10 g19) and 21q21 (rs2823093; P = 1.1 - 10 g12). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.

UR - http://hdl.handle.net/10379/11625

UR - https://www.scopus.com/pages/publications/84862776961

U2 - 10.13025/28712

DO - 10.13025/28712

M3 - Article

SN - 1061-4036

VL - 44

SP - 312

EP - 318

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Abstract

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