Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis

Lee J. Hardwick; Sinead Walsh; Sophie Butcher; Alison Nicod; Jane Shatford; John Bell; Mark Lathrop; B. Paul Wordsworth

Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis

Lee J. Hardwick, Sinead Walsh, Sophie Butcher, Alison Nicod, Jane Shatford, John Bell, Mark Lathrop, B. Paul Wordsworth

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

30 Citations (Scopus)

Abstract

Eighty-nine multicase rheumatoid arthritis families, each containing at least one affected sib pair, have been studied for evidence of genetic linkage to a panel of 315 microsatellite DNA markers. The families were located through the UK national data repository of the Arthritis and Rheumatism Council. Microsatellites were genotyped by semiautomated technology using Applied Biosystems sequencers (ABI 373). Using the SIBPAIR statistical package, linkage to HLA was confirmed (p < 0.0003). Several possible linkages outside HLA were noted, including at least one (p < 0.004) that merits further investigation.

Original language	English
Pages (from-to)	197-198
Number of pages	2
Journal	Journal of Rheumatology
Volume	24
Issue number	1
Publication status	Published - Jan 1997
Externally published	Yes

Keywords

microsatellites
rheumatoid arthritis
susceptibility genes

Cite this

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title = "Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis",

abstract = "Eighty-nine multicase rheumatoid arthritis families, each containing at least one affected sib pair, have been studied for evidence of genetic linkage to a panel of 315 microsatellite DNA markers. The families were located through the UK national data repository of the Arthritis and Rheumatism Council. Microsatellites were genotyped by semiautomated technology using Applied Biosystems sequencers (ABI 373). Using the SIBPAIR statistical package, linkage to HLA was confirmed (p < 0.0003). Several possible linkages outside HLA were noted, including at least one (p < 0.004) that merits further investigation.",

keywords = "microsatellites, rheumatoid arthritis, susceptibility genes",

author = "Hardwick, \{Lee J.\} and Sinead Walsh and Sophie Butcher and Alison Nicod and Jane Shatford and John Bell and Mark Lathrop and Wordsworth, \{B. Paul\}",

year = "1997",

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T1 - Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis

AU - Hardwick, Lee J.

AU - Walsh, Sinead

AU - Butcher, Sophie

AU - Nicod, Alison

AU - Shatford, Jane

AU - Bell, John

AU - Lathrop, Mark

AU - Wordsworth, B. Paul

PY - 1997/1

Y1 - 1997/1

N2 - Eighty-nine multicase rheumatoid arthritis families, each containing at least one affected sib pair, have been studied for evidence of genetic linkage to a panel of 315 microsatellite DNA markers. The families were located through the UK national data repository of the Arthritis and Rheumatism Council. Microsatellites were genotyped by semiautomated technology using Applied Biosystems sequencers (ABI 373). Using the SIBPAIR statistical package, linkage to HLA was confirmed (p < 0.0003). Several possible linkages outside HLA were noted, including at least one (p < 0.004) that merits further investigation.

AB - Eighty-nine multicase rheumatoid arthritis families, each containing at least one affected sib pair, have been studied for evidence of genetic linkage to a panel of 315 microsatellite DNA markers. The families were located through the UK national data repository of the Arthritis and Rheumatism Council. Microsatellites were genotyped by semiautomated technology using Applied Biosystems sequencers (ABI 373). Using the SIBPAIR statistical package, linkage to HLA was confirmed (p < 0.0003). Several possible linkages outside HLA were noted, including at least one (p < 0.004) that merits further investigation.

KW - microsatellites

KW - rheumatoid arthritis

KW - susceptibility genes

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M3 - Article

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AN - SCOPUS:0031017810

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VL - 24

SP - 197

EP - 198

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 1

ER -

Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis

Abstract

Keywords

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