Abstract
AIMS: We sought to examine the magnitude of the differences in SNP allele frequencies between five European populations (Scotland, Ireland, Sweden, Bulgaria and Portugal) and to identify the loci with the greatest differences. METHODS: We performed a population-based genome-wide association analysis with Affymetrix 6.0 and 5.0 arrays. We used a 4 degrees of freedom chi(2) test to determine the magnitude of stratification for each SNP. We then examined the genes within the most stratified regions, using a highly conservative cutoff of p lt; 10(-45). RESULTS: We found 40,593 SNPs which are genome-wide significantly (p
| Original language | English (Ireland) |
|---|---|
| Journal | Heredity |
| Volume | 70 |
| Issue number | 22 |
| Publication status | Published - 1 Jan 2010 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Moskvina, V.,Smith, M.,Ivanov, D.,Blackwood, D.,StClair, D.,Hultman, C.,Toncheva, D.,Gill, M.,Corvin, A.,O'Dushlaine, C.,Morris, D. W.,Wray, N. R.,Sullivan, P.,Pato, C.,Pato, M. T.,Sklar, P.,Purcell, S.,Holmans, P.,O'Donovan, M. C.,Owen, M. J.,Kirov, G.