Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C  A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B)

Veronica Mcinerney; Sanbing Shen; Timothy O'Brien

doi:10.1016/j.scr.2019.101502

Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B)

Veronica Mcinerney, Sanbing Shen, Timothy O'Brien

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

4 Citations (Scopus)

Abstract

Long QT Syndrome type 1 (LQT1), an inherited cardiac ion channelopathy associated with arrhythmias and risk of sudden death, is caused by mutations in KCNQ1 encoding the alpha-subunit of Kv7.1, that affects the slow component of delayed rectifier K+ current (I-KS) channel. In this study, the non-integrational Sendai reprogramming method was used to express four Yamanaka factors and to generate induced pluripotent stem cell (iPSC) lines carrying the KCNQ1 c.1697C A (p.S566Y) mutation from familial LQT1 patients. The patient-specific iPSC lines harbouring the c.1697C A mutation expressed pluripotency markers and had the capacity to differentiate into three germ layers.

Original language	English (Ireland)
Article number	101502
Number of pages	0
Journal	Stem Cell Research
Volume	39
DOIs	https://doi.org/10.1016/j.scr.2019.101502
Publication status	Published - 1 Aug 2019

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Ge, N;Liu, M;Krawczyk, J;McInerney, V;Galvin, J;Shen, S;O'Brien, T;Prendiville, T

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10.1016/j.scr.2019.101502

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Mcinerney, V., Shen, S., & O'Brien, T. (2019). Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B). Stem Cell Research, 39, Article 101502. https://doi.org/10.1016/j.scr.2019.101502

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title = "Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B)",

abstract = "Long QT Syndrome type 1 (LQT1), an inherited cardiac ion channelopathy associated with arrhythmias and risk of sudden death, is caused by mutations in KCNQ1 encoding the alpha-subunit of Kv7.1, that affects the slow component of delayed rectifier K+ current (I-KS) channel. In this study, the non-integrational Sendai reprogramming method was used to express four Yamanaka factors and to generate induced pluripotent stem cell (iPSC) lines carrying the KCNQ1 c.1697C A (p.S566Y) mutation from familial LQT1 patients. The patient-specific iPSC lines harbouring the c.1697C A mutation expressed pluripotency markers and had the capacity to differentiate into three germ layers.",

author = "Veronica Mcinerney and Sanbing Shen and Timothy O'Brien",

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year = "2019",

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Mcinerney, V , Shen, S & O'Brien, T 2019, 'Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B)', Stem Cell Research, vol. 39, 101502. https://doi.org/10.1016/j.scr.2019.101502

Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B). / Mcinerney, Veronica ; Shen, Sanbing ; O'Brien, Timothy.
In: Stem Cell Research, Vol. 39, 101502, 01.08.2019.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

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AB - Long QT Syndrome type 1 (LQT1), an inherited cardiac ion channelopathy associated with arrhythmias and risk of sudden death, is caused by mutations in KCNQ1 encoding the alpha-subunit of Kv7.1, that affects the slow component of delayed rectifier K+ current (I-KS) channel. In this study, the non-integrational Sendai reprogramming method was used to express four Yamanaka factors and to generate induced pluripotent stem cell (iPSC) lines carrying the KCNQ1 c.1697C A (p.S566Y) mutation from familial LQT1 patients. The patient-specific iPSC lines harbouring the c.1697C A mutation expressed pluripotency markers and had the capacity to differentiate into three germ layers.

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