Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient

Jun Ma; Ruiyun Guo; Yongzhou Song; Jing Zhang; Baofeng Feng; Asiamah Ernest Amponsah; Desheng Kong; Jingjing He; Wei Zhang; Aijing Liu; Lin Wei; Sanbing Shen; Timothy O'Brien; Huixian Cui

doi:10.1016/j.scr.2019.101417

Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient

Jun Ma
, Ruiyun Guo
, Yongzhou Song
, Jing Zhang
, Baofeng Feng
, Asiamah Ernest Amponsah
, Desheng Kong
, Jingjing He
, Wei Zhang
, Aijing Liu
, Lin Wei
, Sanbing Shen
, Timothy O'Brien
, Huixian Cui

Clinical Medicine and Population Health

University of Galway
Hebei Research Center for Stem Cell Medical Translational Engineering
Hebei Medical University
The Fourth Hospital of Shijiazhuang

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

13 Citations (Scopus)

Abstract

We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.

Original language	English
Article number	101417
Number of pages	0
Journal	Stem Cell Research
Volume	36
DOIs	https://doi.org/10.1016/j.scr.2019.101417
Publication status	Published - 1 Apr 2019

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Ma, J;Guo, RY;Song, YZ;Zhang, J;Feng, BF;Amponsah, AE;Kong, DS;He, JJ;Zhang, W;Liu, AJ;Wei, L;Shen, SB;O'Brien, T;Cui, HX
Ma, J,Guo, RY,Song, YZ,Zhang, J,Feng, BF,Amponsah, AE,Kong, DS,He, JJ,Zhang, W,Liu, AJ,Wei, L,Shen, SB,O'Brien, T,Cui, HX

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Ma, J., Guo, R., Song, Y., Zhang, J., Feng, B., Amponsah, A. E., Kong, D., He, J., Zhang, W., Liu, A., Wei, L., Shen, S., O'Brien, T., & Cui, H. (2019). Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient. Stem Cell Research, 36, Article 101417. https://doi.org/10.1016/j.scr.2019.101417

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abstract = "We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.",

author = "Jun Ma and Ruiyun Guo and Yongzhou Song and Jing Zhang and Baofeng Feng and Amponsah, \{Asiamah Ernest\} and Desheng Kong and Jingjing He and Wei Zhang and Aijing Liu and Lin Wei and Sanbing Shen and Timothy O'Brien and Huixian Cui",

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AU - Ma, Jun

AU - Guo, Ruiyun

AU - Song, Yongzhou

AU - Zhang, Jing

AU - Feng, Baofeng

AU - Amponsah, Asiamah Ernest

AU - Kong, Desheng

AU - He, Jingjing

AU - Zhang, Wei

AU - Liu, Aijing

AU - Wei, Lin

AU - Shen, Sanbing

AU - O'Brien, Timothy

AU - Cui, Huixian

PY - 2019/4/1

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N2 - We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.

AB - We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.

UR - https://www.scopus.com/pages/publications/85062691303

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DO - 10.1016/j.scr.2019.101417

M3 - Article

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VL - 36

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 101417

ER -

Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient

Abstract

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