Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS

Christos Tapeinos; Aitor Larrañaga; Jose Ramon Sarasua; Abhay Pandit

doi:10.1016/j.nano.2017.03.022

Functionalised collagen spheres reduce H₂O₂ mediated apoptosis by scavenging overexpressed ROS

Christos Tapeinos
, Aitor Larrañaga
, Jose Ramon Sarasua
, Abhay Pandit

University of Galway
University of the Basque Country

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

42 Citations (Scopus)

Abstract

Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H₂O₂-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO₂ nanoparticles acted as ROS scavengers controlling the H₂O₂-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.

Original language	English
Pages (from-to)	2397-2405
Number of pages	9
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	14
Issue number	7
DOIs	https://doi.org/10.1016/j.nano.2017.03.022
Publication status	Published - Oct 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Collagen microspheres
MnO
Oxidative stress
PLGA
ROS scavengers

Access to Document

10.1016/j.nano.2017.03.022

Cite this

@article{3aba61f2dbba4956b70bad5d9bcbdf8b,

title = "Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS",

abstract = "Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.",

keywords = "Apoptosis, Collagen microspheres, MnO, Oxidative stress, PLGA, ROS scavengers",

author = "Christos Tapeinos and Aitor Larra{\~n}aga and Sarasua, \{Jose Ramon\} and Abhay Pandit",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = oct,

doi = "10.1016/j.nano.2017.03.022",

language = "English",

volume = "14",

pages = "2397--2405",

journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",

issn = "1549-9634",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS

AU - Tapeinos, Christos

AU - Larrañaga, Aitor

AU - Sarasua, Jose Ramon

AU - Pandit, Abhay

PY - 2018/10

Y1 - 2018/10

N2 - Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.

AB - Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.

KW - Apoptosis

KW - Collagen microspheres

KW - MnO

KW - Oxidative stress

KW - PLGA

KW - ROS scavengers

UR - https://www.scopus.com/pages/publications/85021358499

U2 - 10.1016/j.nano.2017.03.022

DO - 10.1016/j.nano.2017.03.022

M3 - Article

SN - 1549-9634

VL - 14

SP - 2397

EP - 2405

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

IS - 7

ER -