Abstract
As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.
| Original language | English |
|---|---|
| Pages (from-to) | 1441-1453 |
| Number of pages | 13 |
| Journal | Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine |
| Volume | 224 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2010 |
| Externally published | Yes |
Keywords
- biomaterials
- cell signalling
- differentiation
- focal adhesions