Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective

Paul McVeigh; Aaron G. Maule; John P. Dalton; Mark W. Robinson

doi:10.1016/j.micinf.2011.11.012

Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective

Paul McVeigh
, Aaron G. Maule
, John P. Dalton
, Mark W. Robinson

Research output: Contribution to a Journal (Peer & Non Peer) › Short survey › peer-review

48 Citations (Scopus)

Abstract

Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes.

Original language	English
Pages (from-to)	301-310
Number of pages	10
Journal	Microbes and Infection
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.micinf.2011.11.012
Publication status	Published - Apr 2012
Externally published	Yes

Keywords

Cathepsin
Cysteine peptidase
Fasciola
Proteomics
RNAi
Transcriptomics

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10.1016/j.micinf.2011.11.012

Cite this

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title = "Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective",

abstract = "Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes.",

keywords = "Cathepsin, Cysteine peptidase, Fasciola, Proteomics, RNAi, Transcriptomics",

author = "Paul McVeigh and Maule, \{Aaron G.\} and Dalton, \{John P.\} and Robinson, \{Mark W.\}",

year = "2012",

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journal = "Microbes and Infection",

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TY - JOUR

T1 - Fasciola hepatica virulence-associated cysteine peptidases

T2 - A systems biology perspective

AU - McVeigh, Paul

AU - Maule, Aaron G.

AU - Dalton, John P.

AU - Robinson, Mark W.

PY - 2012/4

Y1 - 2012/4

N2 - Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes.

AB - Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes.

KW - Cathepsin

KW - Cysteine peptidase

KW - Fasciola

KW - Proteomics

KW - RNAi

KW - Transcriptomics

UR - https://www.scopus.com/pages/publications/84857997235

U2 - 10.1016/j.micinf.2011.11.012

DO - 10.1016/j.micinf.2011.11.012

M3 - Short survey

C2 - 22178015

AN - SCOPUS:84857997235

SN - 1286-4579

VL - 14

SP - 301

EP - 310

JO - Microbes and Infection

JF - Microbes and Infection

IS - 4

ER -

Fasciola hepatica virulence-associated cysteine peptidases: A systems biology perspective

Abstract

Keywords

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