TY - JOUR
T1 - Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates
AU - Fitzpatrick, Fidelma
AU - Humphreys, Hilary
AU - O'Gara, James P.
PY - 2005/4
Y1 - 2005/4
N2 - Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.
AB - Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.
UR - https://www.scopus.com/pages/publications/16844369504
U2 - 10.1128/JCM.43.4.1973-1976.2005
DO - 10.1128/JCM.43.4.1973-1976.2005
M3 - Article
SN - 0095-1137
VL - 43
SP - 1973
EP - 1976
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 4
ER -