Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and β-lactamase producing bacteria

Martin G. Cormican; Ronald N. Jones

doi:10.1093/jac/35.4.535

Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and β-lactamase producing bacteria

Martin G. Cormican
, Ronald N. Jones

University of Iowa Carver College of Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

27 Citations (Scopus)

Abstract

Furopenem is a novel orally active penem. In this study, furopenem was highly active in vitro against Streptococcus pneumoniae (MIG₉₀ 0.03 mg/L), Haemophilus influenzae (MIC₉₀, 2 mg/L), and Moraxella catarrhalls (MIG₉₀, 0.5 mg/L). Its activity was not reduced by a variety of β-lactamase enzymes, however β-lactam resistance by other mechanisms was associated with higher MICs.

Original language	English
Pages (from-to)	535-539
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	35
Issue number	4
DOIs	https://doi.org/10.1093/jac/35.4.535
Publication status	Published - Apr 1995
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1093/jac/35.4.535

Cite this

@article{f0cbf10ea4ba49e8a7934219a23094dc,

title = "Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and β-lactamase producing bacteria",

abstract = "Furopenem is a novel orally active penem. In this study, furopenem was highly active in vitro against Streptococcus pneumoniae (MIG90 0.03 mg/L), Haemophilus influenzae (MIC90, 2 mg/L), and Moraxella catarrhalls (MIG90, 0.5 mg/L). Its activity was not reduced by a variety of β-lactamase enzymes, however β-lactam resistance by other mechanisms was associated with higher MICs.",

author = "Cormican, \{Martin G.\} and Jones, \{Ronald N.\}",

year = "1995",

month = apr,

doi = "10.1093/jac/35.4.535",

language = "English",

volume = "35",

pages = "535--539",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and β-lactamase producing bacteria

AU - Cormican, Martin G.

AU - Jones, Ronald N.

PY - 1995/4

Y1 - 1995/4

N2 - Furopenem is a novel orally active penem. In this study, furopenem was highly active in vitro against Streptococcus pneumoniae (MIG90 0.03 mg/L), Haemophilus influenzae (MIC90, 2 mg/L), and Moraxella catarrhalls (MIG90, 0.5 mg/L). Its activity was not reduced by a variety of β-lactamase enzymes, however β-lactam resistance by other mechanisms was associated with higher MICs.

AB - Furopenem is a novel orally active penem. In this study, furopenem was highly active in vitro against Streptococcus pneumoniae (MIG90 0.03 mg/L), Haemophilus influenzae (MIC90, 2 mg/L), and Moraxella catarrhalls (MIG90, 0.5 mg/L). Its activity was not reduced by a variety of β-lactamase enzymes, however β-lactam resistance by other mechanisms was associated with higher MICs.

UR - https://www.scopus.com/pages/publications/0028904678

U2 - 10.1093/jac/35.4.535

DO - 10.1093/jac/35.4.535

M3 - Article

C2 - 7628987

AN - SCOPUS:0028904678

SN - 0305-7453

VL - 35

SP - 535

EP - 539

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and β-lactamase producing bacteria

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this