Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

W. C. Earnshaw; R. C. Allshire; B. E. Black; K. Bloom; B. R. Brinkley; W. Brown; I. M. Cheeseman; K. H.A. Choo; G. P. Copenhaver; J. G. Deluca; A. Desai; S. Diekmann; S. Erhardt; M. Fitzgerald-Hayes; D. Foltz; T. Fukagawa; R. Gassmann; D. W. Gerlich; D. M. Glover; G. J. Gorbsky; S. C. Harrison; P. Heun; T. Hirota; L. E.T. Jansen; G. Karpen; G. J.P.L. Kops; M. A. Lampson; S. M. Lens; A. Losada; K. Luger; H. Maiato; P. S. Maddox; R. L. Margolis; H. Masumoto; A. D. McAinsh; B. G. Mellone; P. Meraldi; A. Musacchio; K. Oegema; R. J. O'Neill; E. D. Salmon; K. C. Scott; A. F. Straight; P. T. Stukenberg; B. A. Sullivan; K. F. Sullivan; C. E. Sunkel; J. R. Swedlow; C. E. Walczak; P. E. Warburton; S. Westermann; H. F. Willard; L. Wordeman; M. Yanagida; T. J. Yen; K. Yoda; D. W. Cleveland

doi:10.1007/s10577-013-9347-y

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

W. C. Earnshaw
, R. C. Allshire
, B. E. Black
, K. Bloom
, B. R. Brinkley
, W. Brown
, I. M. Cheeseman
, K. H.A. Choo
, G. P. Copenhaver
, J. G. Deluca
, A. Desai
, S. Diekmann
, S. Erhardt
, M. Fitzgerald-Hayes
, D. Foltz
, T. Fukagawa
, R. Gassmann
, D. W. Gerlich
, D. M. Glover
, G. J. Gorbsky

S. C. Harrison, P. Heun, T. Hirota, L. E.T. Jansen, G. Karpen, G. J.P.L. Kops, M. A. Lampson, S. M. Lens, A. Losada, K. Luger, H. Maiato, P. S. Maddox, R. L. Margolis, H. Masumoto, A. D. McAinsh, B. G. Mellone, P. Meraldi, A. Musacchio, K. Oegema, R. J. O'Neill, E. D. Salmon, K. C. Scott, A. F. Straight, P. T. Stukenberg, B. A. Sullivan, K. F. Sullivan, C. E. Sunkel, J. R. Swedlow, C. E. Walczak, P. E. Warburton, S. Westermann, H. F. Willard, L. Wordeman, M. Yanagida, T. J. Yen, K. Yoda, D. W. Cleveland

Molecular Biosciences

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

35 Citations (Scopus)

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Chromosome Research
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/s10577-013-9347-y
Publication status	Published - Apr 2013

Keywords

CENP-A
CenH3
centromere
histone
kinetochore

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Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H. A., Copenhaver, G. P., Deluca, J. G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., ... Cleveland, D. W. (2013). Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Research, 21(2), 101-106. https://doi.org/10.1007/s10577-013-9347-y

@article{ca89a89d5caf45919395e67a4cad4157,

title = "Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant",

abstract = "The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.",

keywords = "CENP-A, CenH3, centromere, histone, kinetochore",

author = "Earnshaw, \{W. C.\} and Allshire, \{R. C.\} and Black, \{B. E.\} and K. Bloom and Brinkley, \{B. R.\} and W. Brown and Cheeseman, \{I. M.\} and Choo, \{K. H.A.\} and Copenhaver, \{G. P.\} and Deluca, \{J. G.\} and A. Desai and S. Diekmann and S. Erhardt and M. Fitzgerald-Hayes and D. Foltz and T. Fukagawa and R. Gassmann and Gerlich, \{D. W.\} and Glover, \{D. M.\} and Gorbsky, \{G. J.\} and Harrison, \{S. C.\} and P. Heun and T. Hirota and Jansen, \{L. E.T.\} and G. Karpen and Kops, \{G. J.P.L.\} and Lampson, \{M. A.\} and Lens, \{S. M.\} and A. Losada and K. Luger and H. Maiato and Maddox, \{P. S.\} and Margolis, \{R. L.\} and H. Masumoto and McAinsh, \{A. D.\} and Mellone, \{B. G.\} and P. Meraldi and A. Musacchio and K. Oegema and O'Neill, \{R. J.\} and Salmon, \{E. D.\} and Scott, \{K. C.\} and Straight, \{A. F.\} and Stukenberg, \{P. T.\} and Sullivan, \{B. A.\} and Sullivan, \{K. F.\} and Sunkel, \{C. E.\} and Swedlow, \{J. R.\} and Walczak, \{C. E.\} and Warburton, \{P. E.\} and S. Westermann and Willard, \{H. F.\} and L. Wordeman and M. Yanagida and Yen, \{T. J.\} and K. Yoda and Cleveland, \{D. W.\}",

year = "2013",

month = apr,

doi = "10.1007/s10577-013-9347-y",

language = "English",

volume = "21",

pages = "101--106",

journal = "Chromosome Research",

issn = "0967-3849",

publisher = "Springer Nature",

number = "2",

}

Earnshaw, WC, Allshire, RC, Black, BE, Bloom, K, Brinkley, BR, Brown, W, Cheeseman, IM, Choo, KHA, Copenhaver, GP, Deluca, JG, Desai, A, Diekmann, S, Erhardt, S, Fitzgerald-Hayes, M, Foltz, D, Fukagawa, T, Gassmann, R, Gerlich, DW, Glover, DM, Gorbsky, GJ, Harrison, SC, Heun, P, Hirota, T, Jansen, LET, Karpen, G, Kops, GJPL, Lampson, MA, Lens, SM, Losada, A, Luger, K, Maiato, H, Maddox, PS, Margolis, RL, Masumoto, H, McAinsh, AD, Mellone, BG, Meraldi, P, Musacchio, A, Oegema, K, O'Neill, RJ, Salmon, ED, Scott, KC, Straight, AF, Stukenberg, PT, Sullivan, BA, Sullivan, KF, Sunkel, CE, Swedlow, JR, Walczak, CE, Warburton, PE, Westermann, S, Willard, HF, Wordeman, L, Yanagida, M, Yen, TJ, Yoda, K & Cleveland, DW 2013, 'Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant', Chromosome Research, vol. 21, no. 2, pp. 101-106. https://doi.org/10.1007/s10577-013-9347-y

TY - JOUR

T1 - Esperanto for histones

T2 - CENP-A, not CenH3, is the centromeric histone H3 variant

AU - Earnshaw, W. C.

AU - Allshire, R. C.

AU - Black, B. E.

AU - Bloom, K.

AU - Brinkley, B. R.

AU - Brown, W.

AU - Cheeseman, I. M.

AU - Choo, K. H.A.

AU - Copenhaver, G. P.

AU - Deluca, J. G.

AU - Desai, A.

AU - Diekmann, S.

AU - Erhardt, S.

AU - Fitzgerald-Hayes, M.

AU - Foltz, D.

AU - Fukagawa, T.

AU - Gassmann, R.

AU - Gerlich, D. W.

AU - Glover, D. M.

AU - Gorbsky, G. J.

AU - Harrison, S. C.

AU - Heun, P.

AU - Hirota, T.

AU - Jansen, L. E.T.

AU - Karpen, G.

AU - Kops, G. J.P.L.

AU - Lampson, M. A.

AU - Lens, S. M.

AU - Losada, A.

AU - Luger, K.

AU - Maiato, H.

AU - Maddox, P. S.

AU - Margolis, R. L.

AU - Masumoto, H.

AU - McAinsh, A. D.

AU - Mellone, B. G.

AU - Meraldi, P.

AU - Musacchio, A.

AU - Oegema, K.

AU - O'Neill, R. J.

AU - Salmon, E. D.

AU - Scott, K. C.

AU - Straight, A. F.

AU - Stukenberg, P. T.

AU - Sullivan, B. A.

AU - Sullivan, K. F.

AU - Sunkel, C. E.

AU - Swedlow, J. R.

AU - Walczak, C. E.

AU - Warburton, P. E.

AU - Westermann, S.

AU - Willard, H. F.

AU - Wordeman, L.

AU - Yanagida, M.

AU - Yen, T. J.

AU - Yoda, K.

AU - Cleveland, D. W.

PY - 2013/4

Y1 - 2013/4

N2 - The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

AB - The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

KW - CENP-A

KW - CenH3

KW - centromere

KW - histone

KW - kinetochore

UR - https://www.scopus.com/pages/publications/84880573233

U2 - 10.1007/s10577-013-9347-y

DO - 10.1007/s10577-013-9347-y

M3 - Article

SN - 0967-3849

VL - 21

SP - 101

EP - 106

JO - Chromosome Research

JF - Chromosome Research

IS - 2

ER -

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Abstract

Keywords

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