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ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies

  • the European Society of Intensive Care Medicine Taskforce on ARDS
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
  • University of Milan
  • University of California San Francisco
  • Guys and St Thomas' NHS Foundation Trust
  • King's College London
  • S. Martino Hospital, Belluno
  • University of São Paulo
  • Fondazione Policlinico Universitario A Gemelli IRCCS
  • Catholic University of the Sacred Heart
  • National Guard Health Affairs
  • King Saud bin Abdulaziz University for Health Sciences
  • San Giovanni Hospital
  • Columbia University
  • University of Trento
  • Santa Chiara Hospital
  • University College London
  • Queen's University of Belfast
  • University of Amsterdam
  • Keenan Research Centre for Biomedical Science
  • University of Toronto Faculty of Medicine
  • The Johns Hopkins University School of Medicine
  • Unity Health Toronto
  • Li Ka Shing Knowledge Institute
  • McMaster University
  • Sorbonne Université
  • AP-HP Groupe Hospitalier Pitié—Salpêtrière
  • ULB Center for Diabetes Research
  • Sorbonne Université
  • Shaare Zedek Medical Center
  • Toronto General Research Institute - University Health Network
  • University of Toronto
  • Universitaire La Miletrie
  • Faculté de Médecine et de Pharmacie de l'Université de Poitiers
  • University Medical Centre Göttingen
  • University of Lyon
  • “Translationnal Psychiatry”
  • Monash University
  • Alfred Health
  • Oregon Health and Science University
  • University of Montpellier
  • Erasmus MC
  • Witten/Herdecke University
  • University Medical Centre Utrecht
  • Makerere University
  • Galway University Hospital
  • Hospital de la Santa Creu I
  • Royal Victoria Hospital Belfast
  • SFR ICAT
  • University of Pennsylvania Perelman School of Medicine
  • University of Colorado School of Medicine
  • Sinai Health
  • Tata Memorial Hospital
  • Montefiore Medical Center
  • Albert Einstein College of Medicine
  • Bastia General Hospital Intensive Care Unit
  • Aix-Marseille Université
  • Department of Medicine, The University of Chicago
  • Uppsala University
  • University Hospital of Copenhagen - Rigshospitalet
  • University of Lausanne
  • Southeast University
  • University of Bologna
  • IRCCS Policlinico di Sant’Orsola
  • Harvard Medical School
  • University of Vermont Larner College of Medicine
  • Department of Medicine
  • Massachusetts General Hospital
  • Hospital Israelita Albert Einstein
  • Instituto de Salud Carlos III
  • Hospital Universitario de Gran Canaria Dr.Negrín
  • Vanderbilt University School of Medicine
  • Charité – Universitätsmedizin Berlin
  • University of Alberta, Faculty of Medicine and Dentistry
  • Hopital Saint-Louis
  • Humanitas University
  • Humanitas Research Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

857 Citations (Scopus)

Abstract

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients’ representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.

Original languageEnglish
Pages (from-to)727-759
Number of pages33
JournalIntensive Care Medicine
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 2023

Keywords

  • Acute hypoxemic respiratory failure
  • Acute respiratory distress syndrome
  • Extracorporeal membrane oxygenation
  • Mechanical ventilation
  • Non-invasive ventilation
  • Practice guidelines
  • Prognosis
  • Prone position

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