Epstein-Barr virus specific antibodies in patients with coeliac disease

Shinji Harada; John Greally; Jack Davis; Nancy Synder; Fiona Stevens; Claran McCarthy; David T. Purtilo

doi:10.1007/BF02937215

Epstein-Barr virus specific antibodies in patients with coeliac disease

Shinji Harada, John Greally, Jack Davis, Nancy Synder, Fiona Stevens, Claran McCarthy, David T. Purtilo

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

1 Citation (Scopus)

Abstract

SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

Original language	English
Pages (from-to)	416-421
Number of pages	6
Journal	Irish Journal of Medical Science
Volume	154
Issue number	11
DOIs	https://doi.org/10.1007/BF02937215
Publication status	Published - Nov 1985
Externally published	Yes

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title = "Epstein-Barr virus specific antibodies in patients with coeliac disease",

abstract = "SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.",

author = "Shinji Harada and John Greally and Jack Davis and Nancy Synder and Fiona Stevens and Claran McCarthy and Purtilo, {David T.}",

year = "1985",

month = nov,

doi = "10.1007/BF02937215",

language = "English",

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pages = "416--421",

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AU - Harada, Shinji

AU - Greally, John

AU - Davis, Jack

AU - Synder, Nancy

AU - Stevens, Fiona

AU - McCarthy, Claran

AU - Purtilo, David T.

PY - 1985/11

Y1 - 1985/11

N2 - SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

AB - SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

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VL - 154

SP - 416

EP - 421

JO - Irish Journal of Medical Science

JF - Irish Journal of Medical Science

IS - 11

ER -

Epstein-Barr virus specific antibodies in patients with coeliac disease

Abstract

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