Enzymatic generation of planar chirality in the (arene)Cr(CO)3 series: Experimental results and modelling studies

James A.S. Howell; Michael G. Palin; Gérard Jaouen; Bernard Malezieux; Siden Top; Jean Michel Cense; Jacques Salaün; Patrick McArdle; Desmond Cunningham; Margaret O'Gara

doi:10.1016/0957-4166(95)00425-4

Enzymatic generation of planar chirality in the (arene)Cr(CO)₃ series: Experimental results and modelling studies

James A.S. Howell, Michael G. Palin, Gérard Jaouen, Bernard Malezieux, Siden Top, Jean Michel Cense, Jacques Salaün, Patrick McArdle, Desmond Cunningham, Margaret O'Gara

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

11 Citations (Scopus)

Abstract

Hydrolysis using pig liver esterase of (benzene-1,2-diacetic ester)Cr(CO)₃ complexes generates the half-ester in high enantiomeric purity. The high enantioselectivity may be rationalised through substrate interaction with the Jones active site model of pig liver esterase.

Original language	English
Pages (from-to)	95-104
Number of pages	10
Journal	Tetrahedron Asymmetry
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0957-4166(95)00425-4
Publication status	Published - 1996
Externally published	Yes

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title = "Enzymatic generation of planar chirality in the (arene)Cr(CO)3 series: Experimental results and modelling studies",

abstract = "Hydrolysis using pig liver esterase of (benzene-1,2-diacetic ester)Cr(CO)3 complexes generates the half-ester in high enantiomeric purity. The high enantioselectivity may be rationalised through substrate interaction with the Jones active site model of pig liver esterase.",

author = "Howell, {James A.S.} and Palin, {Michael G.} and G{\'e}rard Jaouen and Bernard Malezieux and Siden Top and Cense, {Jean Michel} and Jacques Sala{\"u}n and Patrick McArdle and Desmond Cunningham and Margaret O'Gara",

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T2 - Experimental results and modelling studies

AU - Howell, James A.S.

AU - Palin, Michael G.

AU - Jaouen, Gérard

AU - Malezieux, Bernard

AU - Top, Siden

AU - Cense, Jean Michel

AU - Salaün, Jacques

AU - McArdle, Patrick

AU - Cunningham, Desmond

AU - O'Gara, Margaret

PY - 1996

Y1 - 1996

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AB - Hydrolysis using pig liver esterase of (benzene-1,2-diacetic ester)Cr(CO)3 complexes generates the half-ester in high enantiomeric purity. The high enantioselectivity may be rationalised through substrate interaction with the Jones active site model of pig liver esterase.

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U2 - 10.1016/0957-4166(95)00425-4

DO - 10.1016/0957-4166(95)00425-4

M3 - Article

SN - 0957-4166

VL - 7

SP - 95

EP - 104

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 1

ER -

Enzymatic generation of planar chirality in the (arene)Cr(CO)₃ series: Experimental results and modelling studies

Abstract

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