TY - JOUR
T1 - Endothelialization of Intravascular Stents
AU - VAN DER GIESSEN, W. J.
AU - SERRUYS, P. W.
AU - VISSER, W. J.
AU - VERDOUW, P. D.
AU - VAN SCHALKWIJK, W. P.
AU - JONGKIND, J. F.
PY - 1988/6
Y1 - 1988/6
N2 - Wide clinical application of intravascular stenting devices is currently limited by occlusion or intraluminal narrowing caused by thrombosis and neointimal thickening in a considerable percentage of implantations. We studied the possibility of seeding one of the currently availiable stents, a stainless steel, self‐expandable wire‐mesh, with endothelial cells in vitro. Endothelial cells, derived from human umbilical cord veins, could be successfully attached to stent filaments. In vivo stent implantations in porcine femoral arteries showed complete covering of stent wires by endothelium after 1 week. We conclude that coating of stents with autologous endothelial cells prior to implantation might protect against early thrombosis during the period in which a neointima is formed. (J Interven Cardiol 1988:1:2)
AB - Wide clinical application of intravascular stenting devices is currently limited by occlusion or intraluminal narrowing caused by thrombosis and neointimal thickening in a considerable percentage of implantations. We studied the possibility of seeding one of the currently availiable stents, a stainless steel, self‐expandable wire‐mesh, with endothelial cells in vitro. Endothelial cells, derived from human umbilical cord veins, could be successfully attached to stent filaments. In vivo stent implantations in porcine femoral arteries showed complete covering of stent wires by endothelium after 1 week. We conclude that coating of stents with autologous endothelial cells prior to implantation might protect against early thrombosis during the period in which a neointima is formed. (J Interven Cardiol 1988:1:2)
UR - https://www.scopus.com/pages/publications/84993890076
U2 - 10.1111/j.1540-8183.1988.tb00395.x
DO - 10.1111/j.1540-8183.1988.tb00395.x
M3 - Article
AN - SCOPUS:84993890076
SN - 0896-4327
VL - 1
SP - 109
EP - 120
JO - Journal of Interventional Cardiology
JF - Journal of Interventional Cardiology
IS - 2
ER -