Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

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Abstract

We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp2-sp3 hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.

Original languageEnglish (Ireland)
Pages (from-to)9148-9151
Number of pages3
JournalJournal of the American Chemical Society
Volume139
Issue number27
DOIs
Publication statusPublished - 1 Jun 2017

Authors (Note for portal: view the doc link for the full list of authors)

  • Authors
  • James R. Smith and Beatrice S. L. Collins and Matthew J. Hesse and Mark A. Graham and Eddie L. Myers and Varinder K. Aggarwal

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