Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer

Sapna Gupta; V. R. Tandon; B. Kapoor; A. Gupta; G. D. Gupta; V. Khajuria

Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer

Sapna Gupta
, V. R. Tandon
, B. Kapoor
, A. Gupta
, G. D. Gupta
, V. Khajuria

Govt. Medical College

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

18 Citations (Scopus)

Abstract

Aim: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. Method: A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3^rd month and 6^th months of therapy. Results: Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. Conclusion: The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Journal of Association of Physicians of India
Volume	54
Issue number	MAR.
Publication status	Published - Mar 2006
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer",

abstract = "Aim: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. Method: A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy. Results: Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. Conclusion: The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.",

author = "Sapna Gupta and Tandon, \{V. R.\} and B. Kapoor and A. Gupta and Gupta, \{G. D.\} and V. Khajuria",

year = "2006",

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language = "English",

volume = "54",

pages = "183--186",

journal = "Journal of Association of Physicians of India",

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}

TY - JOUR

T1 - Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer

AU - Gupta, Sapna

AU - Tandon, V. R.

AU - Kapoor, B.

AU - Gupta, A.

AU - Gupta, G. D.

AU - Khajuria, V.

PY - 2006/3

Y1 - 2006/3

N2 - Aim: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. Method: A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy. Results: Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. Conclusion: The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.

AB - Aim: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. Method: A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy. Results: Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. Conclusion: The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.

UR - https://www.scopus.com/pages/publications/33645151448

M3 - Article

C2 - 16800341

AN - SCOPUS:33645151448

SN - 0004-5772

VL - 54

SP - 183

EP - 186

JO - Journal of Association of Physicians of India

JF - Journal of Association of Physicians of India

IS - MAR.

ER -

Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer

Abstract

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