Abstract
Aim: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. Method: A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy. Results: Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. Conclusion: The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 183-186 |
| Number of pages | 4 |
| Journal | Journal of Association of Physicians of India |
| Volume | 54 |
| Issue number | MAR. |
| Publication status | Published - Mar 2006 |
| Externally published | Yes |
