Abstract
An abnormal fatty acid composition may be related to the immune-inflammatory pathophysiology of major depression. We have examined the effects of dietary supplementation (200 mg kg per day) for 4 weeks with the omega 3 fatty acid rich oils eicosapentanoic acid (EPA) 70 monoester and EPA 95 diester or a omega 6 fatty acid rich oil, nicotinic gamma linoleic acid (Nico GLA) on lipopolysaccharide (LPS)-induced depressive-like behavioural symptoms and interleukin (IL)-1 beta production in the rat. LPS challenge (100 mu g kg; i.p.) produced significant decreases in body weight gain, food intake, consumption of a palatable saccharin solution and nocturnal activity in the home cage in all groups irrespective of the nature of pre-treatment. The LPS challenge also provoked a robust increase in plasma interleukin-1 beta concentrations which was not altered by dietary fatty acid supplementation. These results suggest that dietary supplementation with either omega 3 or omega 6 fatty acids does not alter IL-1 beta secretion or the depressive-like behavioural symptoms provoked by LPS administration in the rat. Med Sci Res 27:291-294 (C) 1999 Lippincott Williams Wilkins.
| Original language | English (Ireland) |
|---|---|
| Number of pages | 3 |
| Journal | Medical Science Research |
| Volume | 27 |
| Publication status | Published - 1 May 1999 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Shen, Y;Connor, TJ;Kelly, JP;Leonard, BE