Effect of splenectomy and the functional hyposplenism of coeliac disease on auto-antibody formation

J. G. O'Grady; F. M. Stevens; B. Harding; J. Flynn; M. P.G. Little; C. F. McCarthy

doi:10.1007/BF02939931

Effect of splenectomy and the functional hyposplenism of coeliac disease on auto-antibody formation

J. G. O'Grady, F. M. Stevens, B. Harding, J. Flynn, M. P.G. Little, C. F. McCarthy

Galway University Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

Auto-antibodies or rheumatoid factor were detected in 10.3% of 78 normal subjects, 16.8% of 89 splenectomised subjects, 15.4% of 39 normosplenic coeliacs and 18.3% of 49 hyposplenic coeliacs. Auto-antibodies tended to occur in older subjects but the presence of hyposplenism did not result in their formation at a younger age. The presence of the HLA-B8 antigen did not significantly effect auto-antibody formation in any of the 3 study populations. We conclude that auto-antibody formation is not influenced by splenic function or the HLA-B8 antigen.

Original language	English
Pages (from-to)	351-354
Number of pages	4
Journal	Irish Journal of Medical Science
Volume	153
Issue number	10
DOIs	https://doi.org/10.1007/BF02939931
Publication status	Published - Oct 1984
Externally published	Yes

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AU - O'Grady, J. G.

AU - Stevens, F. M.

AU - Harding, B.

AU - Flynn, J.

AU - Little, M. P.G.

AU - McCarthy, C. F.

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AB - Auto-antibodies or rheumatoid factor were detected in 10.3% of 78 normal subjects, 16.8% of 89 splenectomised subjects, 15.4% of 39 normosplenic coeliacs and 18.3% of 49 hyposplenic coeliacs. Auto-antibodies tended to occur in older subjects but the presence of hyposplenism did not result in their formation at a younger age. The presence of the HLA-B8 antigen did not significantly effect auto-antibody formation in any of the 3 study populations. We conclude that auto-antibody formation is not influenced by splenic function or the HLA-B8 antigen.

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Effect of splenectomy and the functional hyposplenism of coeliac disease on auto-antibody formation

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