Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise

R. J. Bos; P. W. Serruys; R. W. Brower; H. J. Ten Katen; G. Vanhaleweyk; P. G. Hugenholtz

doi:10.1093/oxfordjournals.eurheartj.a061862

Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise

R. J. Bos, P. W. Serruys, R. W. Brower, H. J. Ten Katen, G. Vanhaleweyk, P. G. Hugenholtz

Erasmus MC

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

4 Citations (Scopus)

Abstract

15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug. Haemodynamic variables were monitored as was epicardial marker motion, using biplane cineradiography during exercise, the markers having been implanted at the time of surgery. We found significant (P<0.001) reductions in end-diastolic and end-systolic regional dimensions at maximal exercise after oral nifedipine, associated with a significant reduction in exertional angina, which persisted during long-term treatment. No adverse effects of the drug were observed.

Original language	English
Pages (from-to)	349-357
Number of pages	9
Journal	European Heart Journal
Volume	6
Issue number	4
DOIs	https://doi.org/10.1093/oxfordjournals.eurheartj.a061862
Publication status	Published - Apr 1985
Externally published	Yes

Keywords

Exercise testing
Nifedipine
Wall motion

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/oxfordjournals.eurheartj.a061862

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title = "Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise",

abstract = "15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug. Haemodynamic variables were monitored as was epicardial marker motion, using biplane cineradiography during exercise, the markers having been implanted at the time of surgery. We found significant (P<0.001) reductions in end-diastolic and end-systolic regional dimensions at maximal exercise after oral nifedipine, associated with a significant reduction in exertional angina, which persisted during long-term treatment. No adverse effects of the drug were observed.",

keywords = "Exercise testing, Nifedipine, Wall motion",

author = "Bos, {R. J.} and Serruys, {P. W.} and Brower, {R. W.} and {Ten Katen}, {H. J.} and G. Vanhaleweyk and Hugenholtz, {P. G.}",

year = "1985",

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doi = "10.1093/oxfordjournals.eurheartj.a061862",

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T1 - Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise

AU - Bos, R. J.

AU - Serruys, P. W.

AU - Brower, R. W.

AU - Ten Katen, H. J.

AU - Vanhaleweyk, G.

AU - Hugenholtz, P. G.

PY - 1985/4

Y1 - 1985/4

N2 - 15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug. Haemodynamic variables were monitored as was epicardial marker motion, using biplane cineradiography during exercise, the markers having been implanted at the time of surgery. We found significant (P<0.001) reductions in end-diastolic and end-systolic regional dimensions at maximal exercise after oral nifedipine, associated with a significant reduction in exertional angina, which persisted during long-term treatment. No adverse effects of the drug were observed.

AB - 15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug. Haemodynamic variables were monitored as was epicardial marker motion, using biplane cineradiography during exercise, the markers having been implanted at the time of surgery. We found significant (P<0.001) reductions in end-diastolic and end-systolic regional dimensions at maximal exercise after oral nifedipine, associated with a significant reduction in exertional angina, which persisted during long-term treatment. No adverse effects of the drug were observed.

KW - Exercise testing

KW - Nifedipine

KW - Wall motion

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DO - 10.1093/oxfordjournals.eurheartj.a061862

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AN - SCOPUS:0021795777

SN - 0195-668X

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JO - European Heart Journal

JF - European Heart Journal

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ER -

Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise

Abstract

Keywords

UN SDGs

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